Decision Letter: Stimulation of Hair Follicle Stem Cell Proliferation Through an IL-1 Dependent Activation of γδT-Cells
July 2017
TLDR IL-1 signaling is crucial for hair follicle stem cell growth and wound healing.
The study investigated the role of γδT cells in hair follicle stem cell proliferation during wound healing, emphasizing the activation by IL-1α. It demonstrated that γδT cells were essential for this proliferation, as their absence impaired the process despite normal IL-1α and IL-7 levels. The research highlighted the sequential roles of IL-1α and macrophages, with IL-1α initiating and macrophages sustaining wound healing. It also found that cell migration was independent of IL-1 signaling. The study provided insights into the interactions between immune cells and cytokines in hair regeneration, noting that dermal γδT-cells were the main source of FGF9 in wounded skin, rather than dendritic epidermal T-cells.
