Decision Letter: Stimulation of Hair Follicle Stem Cell Proliferation Through an IL-1 Dependent Activation of γδT-Cells
July 2017
TLDR IL-1 signaling is crucial for hair follicle stem cell growth and wound healing.
The study explored the role of IL-1 signaling in hair follicle stem cell (HFSC) proliferation during wound healing in mice, revealing that IL-1α and IL-7 secreted by keratinocytes activated γδT-cells, which stimulated HFSC proliferation. This process was essential for effective wound healing, as the absence of IL-1 signaling impaired stem cell proliferation and delayed wound closure. The findings emphasized the importance of IL-1 in mediating interactions between immune cells and stem cells, suggesting potential therapeutic targets for enhancing skin regeneration and treating chronic wounds. Additionally, the study found that γδT-cells were crucial for wound healing, with their absence mimicking the effects of lacking IL-1 signaling, and demonstrated an epistatic relationship between IL-1 signaling and γδT-cell proliferation.
