Egr-1 Is Main Key Regulator in IL-17F-Induced Psoriasin Expression in Human Keratinocytes

The document presents findings from a study that aimed to estimate the comorbidity burden of patients with psoriasis (Pso), focusing on autoimmune diseases. The study used a large US administrative claims database from 2004-2008 to identify 106,128 matched pairs of adult patients with Pso and Pso-free controls, matched by age and gender. The results indicated that Pso patients had a higher mean Charlson comorbidity index (CCI) score than Pso-free patients (1.06 vs 0.74; P<.01) and a significantly higher prevalence of autoimmune diseases such as psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, ulcerative colitis, and Crohn disease, as well as other comorbidities like hypertension, chronic pulmonary diseases, diabetes, hypothyroidism, deficiency anemias, valvular diseases, solid tumor without metastases, psychoses, and peripheral vascular disease (all P < .01). The conclusion was that psoriasis is associated with a substantial comorbidity burden, including a significantly higher prevalence of autoimmune diseases and other physical and mental comorbidities. The study was funded by Celgene Corporation.