Author Response: Stimulation of Hair Follicle Stem Cell Proliferation Through an IL-1 Dependent Activation of γδT-Cells

The study investigated the role of γδT cells in hair follicle stem cell proliferation during wound healing, focusing on the significance of IL-1α. It was found that γδT cells were essential for the early stimulation of hair follicle stem cells, as their absence led to impaired proliferation despite normal cytokine levels. The research clarified experimental conditions and confirmed findings in wildtype mice, distinguishing between cell proliferation and migration, with IL-1α being unnecessary for migration. A model was proposed where IL-1α activates γδT cells early in wound healing, with macrophages later enhancing the response via IL-1β. The study also identified dermal γδT-cells as the main source of FGF9 in wounded skin, while dendritic epidermal T-cells secreted IL1F8 or IL-36β, and emphasized the importance of proper statistical evaluation and manuscript clarity.