TLDR Twist2 is essential for scarless skin healing and hair growth in mouse fetuses.
The study investigates the role of Twist2 in skin regeneration and hair follicle formation in mouse fetuses. Twist2 expression was found to be upregulated in the dermis of embryonic day 13 (E13) wound margins but downregulated in E15 and E17 wounds. Knockdown of Twist2 on E13 resulted in visible marks, inhibited regeneration, and defective follicle formation. Twist2-knockdown dermal fibroblasts lacked the ability to undifferentiate, and Twist2 hetero knockout mice formed visible scars even on E13. These findings suggest that Twist2 is crucial for scarless wound healing and hair follicle regeneration, potentially guiding therapeutic strategies to reduce scarring and promote hair growth.
August 2022 in “Biomedicines” Turning off the Lhx2 gene in mouse embryos leads to slower wound healing and scars.
301 citations
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February 2019 in “Nature Communications” The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.
149 citations
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July 2017 in “PLoS Biology” Hair follicle patterns form through a mix of self-organization and signaling interactions.
21 citations
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June 2016 in “Genesis” Researchers identified specific genes that are important for mouse skin cell development and healing.
359 citations
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January 2015 in “Cold Spring Harbor Perspectives in Medicine” Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
1235 citations
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December 2013 in “Nature” Two fibroblast types shape skin structure and repair differently.
207 citations
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March 2012 in “Development” Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
17 citations
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December 2010 in “Journal of Investigative Dermatology” Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.
