Bacteria Induce Skin Regeneration Via IL-1β Signaling

    January 2020 in “ Social Science Research Network ”
    Gaofeng Wang, Haiyun Liu, Evan Sweren, Eric M. Wier, Martin P. Alphonse, Nasif Islam, Ang Li, Yingchao Xue, Sam Lee, Yu Wang, Nathan K. Archer, Zhiqi Hu, Elizabeth A. Grice, Lloyd S. Miller, Luis A. Garza
    Image of study
    TLDR Skin bacteria help in skin regeneration and wound healing, with a specific signal called IL-1β playing a crucial role.
    The study conducted by researchers from Johns Hopkins University and the University of Pennsylvania in 2019 found that skin bacteria play a role in skin regeneration and wound-induced hair follicle neogenesis (WIHN). The researchers observed varying levels of bacterial burden in wound healing and WIHN, with the lowest levels in germ-free environments, intermediate levels in specific pathogen-free conditions, and the highest levels in mice infected with pathogenic Staphylococcus aureus. The study identified IL-1β and keratinocyte-dependent IL-1R-MyD88 signaling as necessary for bacteria to promote regeneration. In a small clinical trial, it was found that a topical broad-spectrum antibiotic slowed skin wound healing. This suggests that IL-1β controls morphogenesis and challenges the conventional belief that infection inhibits regeneration and small wounds need to be fully sterile.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Verteporfin and Microneedling

      in Treatments 6 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  743 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

    Similar Research

    5 / 1000+ results