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Targeting the skin's endocannabinoid system could help treat skin disorders.

Some systemic treatments work for nail psoriasis but can have serious side effects.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Baricitinib helps treat several diseases, including COVID-19, but has side effects and needs careful monitoring.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Tofacitinib citrate is effective for moderate-to-severe chronic plaque psoriasis but has safety concerns at higher doses.

Autoimmune diseases can cause hair loss, and early treatment is important to prevent permanent damage.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Thymic transplantation normalized some T-cells but not others, maintaining immune function.

The document concludes that lifestyle changes and medical treatments can significantly reduce symptoms of Hidradenitis Suppurativa, a chronic skin condition.

Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.

Non-invasive methods show promise for diagnosing skin diseases like psoriasis and lupus but need more research for regular use.

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

308-nm excimer light therapy helped over a third of treatment-resistant alopecia universalis patients regrow most of their hair.

Men are more likely to have severe respiratory viral infections like COVID-19 due to hormonal and genetic differences, while women generally have stronger immune responses.

New technologies help us better understand how skin microbes affect skin diseases.

Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.

Using a 308-nm excimer lamp with minoxidil promotes hair growth in Alopecia Areata patients, especially younger ones or those with smaller bald spots.

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

Melanocytes are important for skin and hair color and protect the skin from UV damage.

Gray hair can potentially be reversed, leading to new treatments.

Topical vitamin D is effective in treating vitiligo with few side effects.

Some skin conditions may increase the risk of heart disease, but are not yet included in cardiovascular prevention guidelines.

Early treatment of acne is crucial to prevent scarring and psychological effects.