70 citations
,
February 2012 in “Human Reproduction” This study found a high prevalence of clinical signs and functional disorders of androgen excess in premenopausal women, with idiopathic hyperandrogenism and idiopathic hirsutism rates similar to PCOS.
1 citations
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May 2007 in “PubMed” This case study of a subfertile couple highlighted the importance of considering haemochromatosis, particularly involving the C282Y mutation of the HFE gene, in patients with endocrine disorders linked to hypogonadism.
September 2024 in “Cureus” In this study, researchers optimized a method for preparing platelet-rich plasma to improve light transmittance aggregometry testing in coronary artery disease patients on clopidogrel and ticagrelor, finding distinct differences in platelet aggregation and volumes among these patients compared to healthy controls.
4 citations
,
August 2024 in “International Journal of Molecular Sciences” This study found that a combination of natural compounds (escin, bromelain, ginkgo biloba, and sage miltiorrhiza) reduced platelet adhesion to activated endothelium in laboratory settings by inhibiting adhesion molecule transcription and reducing pro-inflammatory cytokines, potentially preventing initial steps of the coagulation cascade.
10 citations
,
October 1992 in “PubMed” This case study suggests that thrombosis was related to anti-phospholipid antibody in a woman with systemic lupus erythematosus, characterized by multiple aseptic bone necroses and arterial blockages.
11 citations
,
November 2021 in “ACS applied nano materials” This study found that keratin-associated protein nanoparticles extracted from human hair significantly reduced clotting time, suggesting their potential as a hemostatic agent for bleeding control, though further research is needed to understand their precise role in coagulation processes.
98 citations
,
November 2014 in “PLoS ONE” In this study, bovine testes hyaluronidase accelerated wound healing in vitro and in vivo by enhancing cellular proliferation, reepithelialization, and modulating inflammation in rat models.
April 2023 in “Clinical and experimental dermatology” This case study highlights the rare occurrence of scarring and nonscarring alopecia following vascular occlusion from dermal filler injections, with the researchers suggesting that a combined treatment including hydroxychloroquine might improve outcomes for this complication.
2 citations
,
November 2023 in “Curēus” This review explores platelet-rich plasma's role in wound healing and discusses its potential as a broadly applicable therapeutic option, but it reports no new clinical results.
1 citations
,
September 2017 in “Asian Journal of Pharmaceutical and Clinical Research” This case report documents warfarin-induced alopecia in a 39-year-old male in Southern India, adding to the limited case reports on this potential side effect.
4 citations
,
June 2019 in “Revista brasileira de ginecologia e obstetrícia” This article discusses the prevalence of hirsutism in women and highlights that many cases exhibit normal androgen levels, suggesting a need for broader diagnostic approaches.
May 2021 in “Clinical Endoscopy” This study found that adding platelet-rich plasma to standard treatment reduced rebleeding in patients with peptic ulcer bleeding compared to additional epinephrine injections.
October 2025 in “Infection Control and Hospital Epidemiology” This article discusses developing a standardized operating procedure for PRP administration to align with infection prevention regulatory standards and reports no new clinical results.
January 2023 in “International journal of dermatology, venereology and leprosy sciences” This study found that patients with alopecia areata had altered levels of inflammatory and coagulation markers, suggesting an association with disease pathogenesis and potential predictive value.
September 2024 in “Journal of the American Academy of Dermatology” In this retrospective case-control study, researchers reported that patients with alopecia areata had significantly increased odds of venous thromboembolism compared to matched controls, suggesting a potential association between alopecia areata and risk of VTE.
46 citations
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January 2007 in “The European Journal of Contraception & Reproductive Health Care” This review discusses the increased risk of venous thromboembolism associated with combined hormonal contraceptives, particularly noting higher risks with certain progestins like desogestrel, gestodene, and cyproterone acetate, but reports no new clinical findings.
July 2024 in “The Journal of Dermatology” This article reported a case where a patient experienced both alopecia areata multiplex and chronic idiopathic thrombocytopenic purpura, an uncommon association, but it did not include specific results or detailed analyses.
August 2022 in “JAAD case reports” This case report describes a 36-year-old woman with hidradenitis suppurativa whose condition progressed to rapidly fatal squamous cell carcinoma, highlighting the potential for aggressive tumor development linked to specific protein markers.
September 2019 in “Encyclopedia of Life Sciences” This review presents an overview of the integrated organ systems involved in wound healing and reports no new findings; the authors emphasize the roles of blood coagulation, immune response, and cellular mechanisms in tissue repair.
44 citations
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June 2024 in “Regenerative Therapy” This review discusses adverse events potentially linked to platelet-rich plasma therapy, highlighting the need for more high-quality evidence to understand its safety profile and associated risks.
December 2015 in “Journal of Neurology and Stroke” This case report describes a 57-year-old man's severe complications, including acute stroke and scalp necrosis, following platelet-rich plasma and stem cell injections for hair restoration.
34 citations
,
March 2012 in “Circulation” This article discusses bridging anticoagulation for patients interrupting warfarin for surgery and highlights the need for the BRIDGE randomized trial to address current uncertainties about its effectiveness and safety.
6 citations
,
April 2022 in “Cellular and Molecular Life Sciences” This study reports that a new protocol using Angio PRP improved wound healing in mice by enhancing key healing processes and regulating inflammation, suggesting potential for clinical advancements.
5 citations
,
June 2012 in “PubMed” This article discusses leukocytoclastic vasculitis, particularly its triggers, manifestations, and treatments, and reports no new experimental results; the authors highlight valproic acid's association with this condition.
3 citations
,
October 2024 in “International Journal of Molecular Sciences” This study found that non-activated platelet-rich plasma from acetylsalicylic acid-treated patients increased inflammatory cytokines, affecting platelet activation and possibly influencing outcomes in PRP therapies.
8 citations
,
August 2020 in “Experimental dermatology” This study observed that platelet-rich plasma samples from female patients show significant variability in growth factor secretion, which may influence the inconsistent clinical response in alopecia treatment.
1 citations
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July 2019 in “The journal of applied laboratory medicine” This review analyzes 873 cases of female hyperandrogenism, primarily attributing it to polycystic ovarian syndrome, and explores sample testing for suspected neoplasms but reports no new clinical findings.
12 citations
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December 2020 in “Frontiers in Cell and Developmental Biology” This review covers the variability in methods for preparing platelet-rich plasma and reports no new clinical results, suggesting that this variability may contribute to inconsistent efficacy in clinical trials.
Testosterone, 4-hydroxyandrostenedione, and finasteride affect blood clotting differently in stressed heart conditions.
January 2025 in “Acta Clinica Croatica” This pilot study found that using platelet rich fibrin in combination with dressings after revascularization surgery in patients with critical limb ischemia accelerated wound healing compared to dressings alone.