Evaluation of Some Biochemical Markers in Alopecia Areata

    January 2023 in “ International journal of dermatology, venereology and leprosy sciences ”
    Rana Abd El Monsef Abd El Wahab Elnemr, Yomna Mazid El‐Hamd Neinaa, Manal Mohammed El Batch, Basma Mourad Mohammed Ali
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    TLDR People with alopecia areata have different blood markers that suggest inflammation and immune system issues compared to healthy individuals.
    The study "Evaluation of some biochemical markers in alopecia areata" involved 25 patients with alopecia areata (AA) and 25 healthy individuals. The researchers found that AA patients had significantly lower mean corpuscular hemoglobin (MCH) and platelet counts, and higher white blood cell (WBC) counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), D-dimer, and thyroid stimulating hormone (TSH) levels. These markers were found to be predictive of the disease occurrence. CRP and D-dimer levels showed the best diagnostic performance with sensitivities of 92% for both, and specificities of 80% and 76%, respectively. The study concluded that there is an association between coagulation system dysfunction, acute inflammatory state, and autoimmune reactions in AA.
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