Keratin-Associated Protein Nanoparticles as Hemostatic Agents

November 2021 in “ ACS applied nano materials ”

Wei-Fan Lu, Tingyu Lu, Yichen Liu, Tai-Hung Liu, Ching-Chih Feng, Chan-Shing Lin, Kai-Chiang Yang, Yang Wei, Jihong Yu

keratin-associated protein nanoparticles KAPNPs keratin human hair

Studysummary This study found that keratin-associated protein nanoparticles extracted from human hair significantly reduced clotting time, suggesting their potential as a hemostatic agent for bleeding control, though further research is needed to understand their precise role in coagulation processes.

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research Effect of Varied Hair Protein Fractions on the Gel Properties of Keratin/Chitosan Hydrogels for Use in Tissue Engineering

41 citations , July 2020 in “Colloids and surfaces. B, Biointerfaces”

This study suggests that adjusting the ratios of keratin-associated proteins to keratin intermediate filaments can create keratin/chitosan hydrogels with more consistent gel properties for tissue engineering.

research Effect of Thermal Treatments on the Structural Change and Hemostatic Property of Hair Extracted Proteins

8 citations , March 2020 in “Colloids and surfaces. B, Biointerfaces”

This study suggests that extracting hair proteins at relatively high temperatures may enhance their hemostatic properties by altering their secondary structure and increasing the precipitation of soluble fibrinogen.

research Reactive Keratin Derivatives: A Promising Strategy for Covalent Binding to Hair

20 citations , September 2018 in “Journal of colloid and interface science”

This study found that keratin derivatives with functionalized thiol groups improved binding to both natural and bleached hair fibers, suggesting a promising strategy for enhancing keratin's durability in hair repair.

research Recombinant Human Hair Keratin Proteins for Halting Bleeding

27 citations , April 2018 in “Artificial Cells Nanomedicine and Biotechnology”

This study reported that recombinant human hair keratins, K37 and K81, showed higher purity and enhanced fibrin clot formation compared to traditional extracts, reducing bleeding time and blood loss in rat injury models.

research Molecular Modeling and Structural Characterization of a High Glycine–Tyrosine Hair Keratin Associated Protein

16 citations , January 2017 in “Physical chemistry chemical physics/PCCP. Physical chemistry chemical physics”

This study presents computational modeling and experimental analysis of the HGT protein KAP8.1, identifying key structural features that may influence hair's response to environmental conditions.

research Wool Keratin-Associated Protein Genes in Sheep: A Review

98 citations , May 2016 in “Genes”

This review explains the genetic diversity of sheep wool keratin-associated protein genes and explores how this variation might be leveraged for selective breeding to enhance wool fiber traits.

research Human Hair Keratin and Its-Based Biomaterials for Biomedical Applications

115 citations , August 2014 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine”

Human hair keratin can be used in many medical applications.

research The Effect of Human Hair Keratin Hydrogel on Early Cellular Response to Sciatic Nerve Injury in a Rat Model

105 citations , May 2013 in “Biomaterials”

In this study, the researchers found that a keratin hydrogel filler in nerve conduits led to earlier Schwann cell migration and improved cellular behaviors compared to other fillers in a rat sciatic nerve model.

research Hemostatic Properties and the Role of Cell Receptor Recognition in Human Hair Keratin Protein Hydrogels

118 citations , January 2013 in “Biomaterials”

This study characterized keratin-based biomaterials that self-assemble into hydrogels, demonstrating their potential to achieve hemostasis in a lethal liver injury model through specific biomaterial-receptor interactions.

research A Novel Purification Procedure for Keratin-Associated Proteins and Keratin from Human Hair

54 citations , January 2013 in “Journal of Biological Macromolecules”

This study proposes a new method to selectively isolate keratin-associated proteins and keratin from human hair, suggesting that KAPs may support keratin fibers in hair structure.

research Characterization of the Human Hair Keratin-Associated Protein 2 (KRTAP2) Gene Family

52 citations , April 2012 in “Journal of Investigative Dermatology”

This study found that KRTAP2 proteins predominantly express in the hair shaft cortex of humans, interact with hair keratins, and play crucial roles in hair shaft keratinization.

research A Review of Keratin-Based Biomaterials for Biomedical Applications

517 citations , February 2010 in “Materials”

This review discusses the history and development of keratin biomaterials for biomedical uses, highlighting their biological activity and biocompatibility, and provides no new research findings.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified 16 novel high sulfur KAP genes and two KAP pseudogenes on chromosome 21q23, showing expression in a specific region of the hair fiber cuticle.

research A Rapid Extraction Procedure of Human Hair Proteins and Identification of Phosphorylated Species

226 citations , January 2002 in “Biological and Pharmaceutical Bulletin”

This study developed a rapid method to extract proteins from human hair, revealing phosphorylation on serine and threonine residues in alpha-keratins and matrix proteins.