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This case study highlights the importance of considering broad causes when evaluating hot flashes in middle-aged men, as it detailed a pituitary macroadenoma causing secondary hypogonadism in a man presenting with such symptoms.

Alopecia areata may involve stress-related changes affecting hormone receptors, leading to reduced cortisol production.

This case report highlights Leydig cell hyperplasia as a rare cause of increased testosterone and postmenopausal hirsutism, resolved after bilateral salpingo-oophorectomy in a 64-year-old woman.

This case study reports that in an 8-year-old male, a pituitary adenoma causing isolated high LH secretion led to early testosterone-driven puberty without typical testicular enlargement, highlighting the differential roles of LH and FSH in pubertal development.

This article discusses the role of androgens in causing hirsutism and male pattern baldness in women and emphasizes the need for antiandrogen treatment to manage these conditions, without reporting new clinical results.

In this study, testosterone was found to increase the risk of arrhythmias in a rat heart model, while finasteride reduced this arrhythmogenic effect.

This case report highlights the need to assess postmenopausal women with hirsutism for hyperandrogenism causes, as exemplified by a Leydig cell tumor coinciding with primary hyperparathyroidism.

This case report describes a domestic shorthaired cat with pituitary-dependent hyperadrenocorticism treated with trilostane, which improved clinical signs, but the cat later succumbed to renal failure due to a fungal urinary tract infection.

In this case study, prolonged selective suppression of adrenal androgens by glucocorticoids was most likely attributed to the observed loss of pubic and axillary hair in a woman post-bilateral oophorectomy.

The woman's rare combination of diseases suggests an unknown factor may predispose individuals to multiple endocrine diseases.

This study examined the incidence of hyperkalemia in women over 65 with female pattern hair loss and spironolactone use, but the findings on risk remain unclear.

This review discusses the potential and varied uses of spironolactone in dermatological conditions such as acne, hidradenitis suppurativa, hirsutism, and female pattern androgenetic alopecia, emphasizing dosage, treatment recommendations, and adverse effects for practical clinical use.

This case report highlighted a rare instance of Cushing's syndrome caused by ectopic ACTH from cervical cancer, demonstrating diagnostic challenges, treatment complexity, and high risks of morbidity and mortality, with less than 10 cases documented overall.

This review examines the diverse roles of SRD5α enzymes across species, focusing on their involvement in steroid synthesis, sexual development, and various physiological processes, but reports no new clinical results.

In this study, researchers identified and examined males with 17 beta-HSD3 deficiency in a highly inbred Arab population, noting genetic findings and the progression of male characteristics despite being raised as females initially.

This study demonstrated that stress-derived neurosteroid THDOC shifts from inhibiting to activating the HPA axis under stress, presenting potential therapeutic targets for stress-related disorders.

This review discusses female hyperandrogenism, detailing diagnostic criteria and treatment options without reporting new study results; it emphasizes improving health and quality of life for affected women.

This case report describes ALP elevation in a patient with severe OA that normalized after bilateral knee replacements, highlighting a potential link between OA and ALP levels.

This study found that androgen deprivation therapy is associated with an increased risk of acquired long-QT syndrome and Torsades de Pointes, particularly highlighting enzalutamide's greater association with sudden death compared to other therapies.

This study identified enzymes responsible for regulating androgen action in the human prostate, suggesting that inhibiting AKR1C2 or RL-HSD may have therapeutic potential in androgen insufficiency or benign prostatic hyperplasia, respectively.

This case study reported on a 62-year-old woman with ovarian hyperthecosis, which caused symptoms like hirsutism and elevated testosterone; after bilateral oophorectomy, her symptoms improved, suggesting the importance of considering this rare condition in hyperandrogenism diagnosis for postmenopausal women.

This case report describes a 35-year-old woman with a Rathke’s cleft cyst presenting with Cushing disease, highlighting the need to evaluate hormonal hypersecretion in atypical pituitary lesions.

This study reported a significant increase in the use of spironolactone for treating acne and hidradenitis suppurativa in female adolescents, noting a 2- to 3-fold rise in prescriptions and suggesting improved tolerance compared to adults, though its efficacy in adolescents is less pronounced.

This case report presents a 60-year-old woman with virilization and elevated adrenal androgens, where a bilateral salpingo-oophorectomy confirmed ovarian steroid cell tumor NOS, and her symptoms resolved post-operatively.

This study concluded that neither basal nor ACTH-stimulated 17-OHP concentrations effectively indicate carrier status for 21-hydroxylase deficiency among Slovenian hyperandrogenic women, recommending molecular analysis of the CYP21 gene for reliable screening.

This case report describes an adolescent girl with polycystic ovarian syndrome and endogenously elevated androgen levels who developed a hepatic adenoma, suggesting a link between the two conditions.

This case report describes a male child with alopecia areata and renal dysgenesis, highlighting a possible coincidental association that may require future genetic investigation.

This review discusses recent advancements in understanding and managing congenital adrenal hyperplasia, including improvements in screening, diagnostics, and potential genetic and cell-based treatments, but reports no new clinical findings.

In this case report, a rare association between Cushing's syndrome caused by ectopic ACTH from cervical cancer is documented, highlighting the diagnostic challenges, treatment complexity, and high morbidity and mortality, with the patient succumbing to septic shock post-surgery.

This study found that individuals with alopecia areata experience variations in cortisol and insulin levels and adaptive mechanism pressures, which may serve as potential therapeutic targets.