An Implication for Post-Transcriptional Control: Reciprocal Changes of Melanocortin Receptor Type 2 mRNA and Protein Expression in Alopecia Areata

    October 2010 in “ Medical Hypotheses ”
    Hongwei Guo, Jun Deng, Xichuan Yang … Fei Hao
    Studysummary Alopecia areata may involve stress-related changes affecting hormone receptors, leading to reduced cortisol production.
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    Research cited in this study 10

    1. Melanocortin Receptor Type 2 (MC2R, ACTH Receptor) Expression in Patients with Alopecia Areata Experimental Dermatology · 2010
    2. The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results Experimental dermatology · 2008
    3. Alopecia Areata: Pathogenesis, Genetic Factors, and Treatments Using Mouse Models KARGER eBooks · 2008
    4. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    5. Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata Journal of Clinical Investigation · 2007
    6. Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control Experimental Dermatology · 2005
    7. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    8. Guidelines for the Management of Alopecia Areata British Journal of Dermatology · 2003
    9. Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003
    10. Why Steroids May Not Always Work in Alopecia Areata: Elevated Unoccupied Glucocorticoid Receptors and Decreased Levels of Thioredoxin Dermatologic Therapy · 2001