Melanocortin Receptor Type 2 (MC2R, ACTH Receptor) Expression in Patients with Alopecia Areata

June 2010 in “ Experimental Dermatology ”

Hongwei Guo, Jun Deng, Xichuan Yang, Zhong Bai‐yu, Zhu Shen, Shaoyan Yang, Liu Bao‐heng, Fei Hao

melanocortin receptor type 2 MC2R adrenocorticotropic hormone ACTH alopecia areata hair follicles sebaceous glands eccrine glands dermal fibroblasts epithelial cells ACTH receptor AA

Studysummary This study reported that patients with alopecia areata have reduced expression of the melanocortin receptor MC2R in their scalp tissues compared to normal scalp, indicating potential involvement in the condition's pathophysiology.

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research Alopecia Areata: Pathogenesis, Genetic Factors, and Treatments Using Mouse Models

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research Neuroimmunoendocrine Circuitry of the Brain-Skin Connection

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This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.

research Corticotropin-Releasing Hormone: An Autocrine Hormone That Promotes Lipogenesis in Human Sebocytes

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In vitro, this study suggests that CRH may act as an autocrine hormone in human sebocytes, influencing lipid synthesis and potentially impacting skin disorders related to alterations in sebaceous lipid formation.

research Why Steroids May Not Always Work in Alopecia Areata: Elevated Unoccupied Glucocorticoid Receptors and Decreased Levels of Thioredoxin

2 citations , December 2001 in “Dermatologic Therapy”

This study found elevated unoccupied type II GC receptors and decreased thioredoxin levels in alopecia areata patients' scalps, which may explain the variable effectiveness of glucocorticoid treatment for hair regrowth.