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Did you mean Melanocortin 1 Receptor?

Glossary Melanocortin 1 Receptor

regulates melanin production, affecting hair and skin color

The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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research Melanocortin receptor type 2 (MC2R, ACTH receptor) expression in patients with alopecia areata

22 citations , June 2010 in “Experimental Dermatology”

This study reported that patients with alopecia areata have reduced expression of the melanocortin receptor MC2R in their scalp tissues compared to normal scalp, indicating potential involvement in the condition's pathophysiology.

research An implication for post-transcriptional control: Reciprocal changes of melanocortin receptor type 2 mRNA and protein expression in alopecia areata

7 citations , October 2010 in “Medical Hypotheses”

Alopecia areata may involve stress-related changes affecting hormone receptors, leading to reduced cortisol production.

research Piecing together the pigment-type switching puzzle

10 citations , November 2009 in “Pigment cell & melanoma research”

This study by Pérez-Oliva et al. explored how Mahogunin Ring Finger-1 (MGRN1) affects melanocortin-1 receptor (MC1R) signaling, suggesting that MGRN1 competitively inhibits Gαs binding to MC1R, influencing pigment production.

research Regrowth of black hair in two red‐haired alopecia areata patients

5 citations , February 2012 in “Australasian Journal of Dermatology”

This case report documents two instances of red-haired men with patch-type alopecia areata, where hair regrowth occurred in black rather than red, an unusual phenomenon potentially linked to pigmentation and receptor pathways.

research 457 Impact of alpha-melanocyte-stimulating hormone on mitochondrial function in human dermal fibroblasts

November 2025 in “Journal of Investigative Dermatology”

Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.

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