Virilization Secondary to Leydig Cell Ovarian Tumor in a Postmenopausal Woman with Primary Hyperparathyroidism

This case study reports on a 66-year-old postmenopausal woman with significant hirsutism and primary hyperparathyroidism, who was found to have a Leydig cell tumor in her left ovary. The tumor was androgen-secreting, leading to elevated testosterone levels (14.8 nmol/L) and symptoms such as frontal balding and terminal hair growth. After surgical removal of the tumor, her testosterone levels became undetectable, and facial hair growth reduced. The study highlights the importance of investigating postmenopausal hyperandrogenism, as it can be indicative of rare conditions like androgen-secreting ovarian tumors.