Virilization Secondary to Leydig Cell Ovarian Tumor in a Postmenopausal Woman with Primary Hyperparathyroidism
May 2025
in “
Journal of the ASEAN Federation of Endocrine Societies
”
Studysummary This case report highlights the need to assess postmenopausal women with hirsutism for hyperandrogenism causes, as exemplified by a Leydig cell tumor coinciding with primary hyperparathyroidism.
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This case study reports on a 66-year-old postmenopausal woman with significant hirsutism and primary hyperparathyroidism, who was found to have a Leydig cell tumor in her left ovary. The tumor was androgen-secreting, leading to elevated testosterone levels (14.8 nmol/L) and symptoms such as frontal balding and terminal hair growth. After surgical removal of the tumor, her testosterone levels became undetectable, and facial hair growth reduced. The study highlights the importance of investigating postmenopausal hyperandrogenism, as it can be indicative of rare conditions like androgen-secreting ovarian tumors.
