Androgenic Effects on Ventricular Repolarization: A Translational Study from Pharmacovigilance Databases to iPSC-Cardiomyocytes

October 2019 in “ European heart journal ”

Joe‐Elie Salem, Tao Yang, Javid Moslehi, Xavier Waintraub, Estelle Gandjbakhch, Anne Bachelot, Françoise Hidden‐Lucet, Jean‐Sébastien Hulot, Björn C. Knollmann, Bénédicte Lebrun‐Vignes, Christian Funck‐Brentano, Andrew M. Glazer, Dan M. Roden

androgen-deprivation therapies acquired long-QT syndrome Torsades de Pointes sudden death enzalutamide androgen antagonist dihydrotestosterone induced pluripotent stem cells cardiomyocytes early afterdepolarizations delayed afterdepolarizations triggered activity IKr block testosterone hypogonadism ADT aLQT TdP SD DHT IPS-CMs ECGs

Studysummary This study found that androgen deprivation therapy is associated with an increased risk of acquired long-QT syndrome and Torsades de Pointes, particularly highlighting enzalutamide's greater association with sudden death compared to other therapies.

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