ACTH-Dependent Cushing's Syndrome Due to Metastatic Cervical Cancer: A Case Report

This case report describes a rare instance of ACTH-dependent Cushing's syndrome associated with metastatic cervical cancer in a 39-year-old woman, highlighting the diagnostic challenges and treatment complexities. The patient initially presented with symptoms such as abnormal uterine bleeding and was diagnosed with endometrioid adenocarcinoma. After losing follow-up, she developed symptoms indicative of Cushing's syndrome, including behavioral changes, muscle weakness, and hirsutism. Laboratory tests confirmed elevated ACTH and cortisol levels, and imaging revealed metastatic liver lesions and adrenal enlargement. Despite treatment attempts with Etomidate and Ketoconazole, and a subsequent bilateral adrenalectomy, the patient succumbed to septic shock shortly after surgery. This case underscores the high morbidity and mortality risks associated with this rare condition, with fewer than 10 similar cases reported.