Adaptive Regulatory Mechanisms of Alopecia Areata

November 2017 in “ PubMed ”

L.А. Bolotna, Inessa Serbina

alopecia areata cortisol insulin Dermatologic Life Quality Index hormonal response adaptive tension AA DLQI

TLDR Alopecia areata progression is linked to stress and hormone changes, suggesting new treatment targets.

The study assessed adaptive hormones and stress in 48 patients with alopecia areata (AA), aged 18 to 52, finding that maladaptive processes were linked to disease progression. A positive correlation was observed between the Dermatologic Life Quality Index (DLQI) and factors such as early age, severe stage, and prolonged hair loss. Two hormonal response types were identified: variations in cortisol and insulin levels based on AA activity and severity. An increased coefficient "K" indicated heightened adaptive tension in patients with severe, progressing AA lasting up to 3 years, while a decreased "K" in cases over 3 years suggested adaptive mechanism depletion. These findings highlighted potential therapeutic targets for AA.

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