Diabetes, Ovarian Tumor, Hyperparathyroidism, and Papillary Cancer: A Chance Association?

The document describes a 65-year-old woman with a rare combination of primary hyperparathyroidism, papillary thyroid carcinoma, ovarian steroid cell tumor, and type 2 diabetes mellitus. She exhibited symptoms of hyperandrogenism, such as increased facial hair and hair loss, which were linked to elevated levels of calcium, parathyroid hormone, and testosterone. After undergoing surgeries for the parathyroid and thyroid conditions, her hyperandrogenism symptoms improved following a bilateral oophorectomy, leading to partial hair recovery. Her hormonal levels normalized three months post-surgery, but two years later, she developed diabetes, initially requiring insulin but later managed with oral medications. The co-occurrence of these conditions is considered atypical, suggesting the possibility of an unknown predisposing factor for such endocrine diseases.