Hepatic Adenoma in an Adolescent With Elevated Androgen Levels

    April 2007 in “ Journal of pediatric gastroenterology and nutrition ”
    Maria Triantafyllopoulou, Peter F. Whitington, Héctor Melín-Aldana, Ellen C Benya, Wendy J. Brickman
    Image of study
    TLDR A teenage girl with high androgen levels and PCOS developed a rare liver tumor, suggesting a possible link between high androgens and the tumor's growth.
    The document reports the case of a 13-year-old obese Hispanic girl with polycystic ovarian syndrome (PCOS), type 2 diabetes mellitus, and elevated androgen levels who developed a hepatic adenoma (HA), a rare benign liver tumor. This is notable as HA has been associated with exogenous androgen use, but there is limited literature on its association with endogenous androgens. The patient's HA was surgically resected, and her androgen levels remained elevated post-surgery. Treatment with metformin was initiated for her insulin resistance, which led to some improvement in her condition, but her androgen levels did not normalize. The case suggests a potential link between elevated androgen levels and the development of HA, although the exact role of androgens in HA pathogenesis remains unclear. The patient's HA did not show androgen receptor staining, which is inconsistent with some previous findings in HA pathology. The document emphasizes the rarity of HA in the pediatric population and the need for further research into the hormonal regulation of HA development.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  53 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community having hair loss as a teen SUCKS. A LOT.

      in Female  12 upvotes 2 years ago
      A teenage girl who has been diagnosed with ADA and is struggling with hair loss, which has caused her to lose confidence. She is looking for recommendations on treatments such as finasteride or Minoxidil, and lifestyle advice including vitamins and other supplements that might help with the issue.

      community How does hair loss and recovery work?

      in Chat  12 upvotes 3 months ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

    Similar Research

    6 / 1000+ results