ACTH-Dependent Cushing's Syndrome Due to Metastatic Cervical Cancer: A Case Report

This case report describes a rare instance of ACTH-dependent Cushing's syndrome caused by metastatic cervical cancer in a 39-year-old woman. The patient initially presented with symptoms such as abnormal uterine bleeding and was diagnosed with endometrioid adenocarcinoma. After initial treatment and a period of lost follow-up, she developed symptoms indicative of Cushing's syndrome, including hypertension, hyperglycemia, and hirsutism. Laboratory tests confirmed elevated levels of ACTH and cortisol. Imaging revealed metastatic liver lesions and adrenal enlargement. Despite treatment attempts with Etomidate and Ketoconazole, and a subsequent bilateral adrenalectomy, the patient succumbed to septic shock shortly after surgery. This case highlights the diagnostic challenges, treatment complexity, and high morbidity and mortality associated with this rare condition, with fewer than 10 similar cases reported.