61 citations,
January 2011 in “PloS one” Notch signaling is essential for healthy skin and hair follicle maintenance.
59 citations,
August 2004 in “Human Reproduction Update” Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.
56 citations,
February 2015 in “F1000 prime reports” Root hair growth in plants is a complex process controlled by many factors working together.
55 citations,
December 2021 in “BMC Veterinary Research” Certain genes in Iranian sheep are linked to wool production and heat adaptation.
53 citations,
March 2003 in “Journal of Investigative Dermatology” Human skin cells have a high-affinity system for biotin transport, crucial for skin health.
51 citations,
April 2020 in “Cells” Special cell particles from macrophages can help hair grow.
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September 2020 in “Frontiers in Immunology” Loss of OGG1 increases skin inflammation and auto-antibodies in lupus.
48 citations,
May 2019 in “Genome Biology” Researchers found that certain RNA circles in the brain are linked to disease risk, but their exact role in disease is still unknown.
42 citations,
June 2019 in “Aging” 3,4,5-tri-O-caffeoylquinic acid promotes hair growth by activating the β-catenin pathway.
41 citations,
May 2020 in “Frontiers in immunology” Hidradenitis suppurativa might be a type of autoinflammatory skin disease.
40 citations,
July 2015 in “Kidney International” IL-3 worsens lupus nephritis and blocking it improves kidney health.
40 citations,
October 2012 in “Dermatologic clinics” More research is needed to understand the genetic causes of Alopecia areata to develop better treatments.
39 citations,
September 2007 in “BMC developmental biology” Neuregulin3 affects cell development in the skin and mammary glands.
34 citations,
June 2015 in “Journal of cardiovascular pharmacology and therapeutics” Direct vasodilators and sympatholytic agents are still useful for certain conditions despite being less common due to side effects and newer drugs.
33 citations,
January 2018 in “Blood” Ruxolitinib helps protect skin stem cells and keeps skin healthy in mice with skin GVHD.
32 citations,
April 2017 in “Scientific Reports” Platelet-rich plasma can help grow more mouse hair follicles, but it doesn't work for human hair follicles yet.
31 citations,
May 2013 in “Clinical Cosmetic and Investigational Dermatology” Proper skin care and dermocosmetics improve skin issues in diabetes patients.
30 citations,
October 2013 in “BMC dermatology” VEGF gel increases hair growth but may have potential toxicity.
29 citations,
October 2020 in “Environmental health perspectives” Five preservatives may disrupt hormone function and need more health and environmental risk assessment.
28 citations,
June 2021 in “Frontiers in immunology” A protein called lfTSLP is important in causing allergic and other skin diseases and could be a target for treatment.
28 citations,
September 2014 in “Journal of Veterinary Internal Medicine” VDC-1101 shows potential as a treatment for canine cutaneous T-cell lymphoma.
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December 2005 in “Oncogene” 25 citations,
June 2017 in “Neuropharmacology” Increasing TSPO in the brain reduces anxiety and depression.
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June 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” VDR regulation varies by tissue and is crucial for its biological functions.
25 citations,
April 2017 in “PloS one” Certain genetic variations in the FST gene are linked to better wool quality in Chinese Merino sheep.
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March 2020 in “Cells” Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.
24 citations,
January 2018 in “Development” Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.
23 citations,
January 2016 in “Frontiers in immunology” Using low-dose IL-2 to increase regulatory T cells might be a safe way to treat type 1 diabetes without severe side effects.
22 citations,
June 2017 in “Advances in Clinical and Experimental Medicine” Polycystic ovary syndrome (PCOS) was first described in 1721, officially diagnosed in the 1990s, and is now known to be partly genetic and linked to insulin resistance, with increased risk of cardiovascular disease and carbohydrate metabolism issues.
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August 1999 in “Mechanisms of Development” Pmg-1 and Pmg-2 are new genes important for skin and mammary gland development.