Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes

January 2016 in “ Frontiers in immunology ”

Minh N. Pham, Matthias G. von Herrath, José Luis Vela

TLDR Using low-dose IL-2 to increase regulatory T cells might be a safe way to treat type 1 diabetes without severe side effects.

The document reviewed the potential of low-dose interleukin-2 (IL-2) therapy to treat Type 1 Diabetes (T1D) by expanding regulatory T cells (Tregs) to restore immune tolerance and prevent autoimmune destruction of pancreatic beta cells. Studies, including a phase 1/2 trial with 24 patients, showed that low-dose IL-2 was well-tolerated and increased Tregs without significantly affecting other immune cells. The therapy also showed promise in treating other autoimmune diseases like alopecia areata and graft-versus-host disease (GVHD). However, further research with larger sample sizes and reliable biomarkers is needed to confirm long-term efficacy and optimize dosing strategies.

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2 / 2 results

research Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata

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Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes

Research cited in this study

research Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

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