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BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.

Spermidine may help reduce hair loss and deserves further testing as a treatment.

Sostdc1 controls the size and number of hair and mammary gland structures.

Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.

High ornithine decarboxylase levels may lead to hair loss and cancer by increasing CK2 activity in the nucleus.

Melatonin, usually known for sleep regulation, also has antioxidant properties that can protect skin, stimulate hair growth, and improve skin conditions, with topical application being more effective than oral use.

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

Low selenium levels can extend lifespan but worsen health issues.

TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

Finasteride and dutasteride are equally effective and safe for treating benign prostatic hyperplasia.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

Polycystic Ovary Syndrome (PCOS) in teenagers is a complex condition linked to genetics and environment, often associated with obesity and insulin resistance, and is treated with lifestyle changes and medication.

Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.

New treatments for non-small cell lung cancer are being tested, with some already in use, focusing on immune response and targeting cancer cells, but side effects vary.

Certain genetic variations in the RAB5B gene are linked to a higher risk of polycystic ovary syndrome in Chinese Han women.

B6.Cg-Tyr c−2J Hr hr /J mice have a stronger delayed sunburn reaction and are good for UV research.

Sorafenib causes skin reactions by increasing the number and activity of skin mast cells.

Melanin may help melanoma cells grow by aiding their metabolism.

Plumbagin may help protect cells, reduce inflammation, and has potential for treating various diseases, but more research is needed.

Tadalafil and Finasteride may help treat aggressive melanoma.

Oxidative stress and immune dysfunction are linked to both Hashimoto's thyroiditis and polycystic ovary syndrome, with diet and specific treatments important for managing these conditions.

Preventing cancer involves lifestyle changes, vaccinations, early screening, and understanding cancer's molecular basis.

Hair analysis can help diagnose adrenal disorders non-invasively.

Platycladus orientalis leaf extract helps hair grow by activating certain proteins.

Geriatric Julia Creek dunnarts often suffer from reproductive and skin diseases, impacting conservation efforts.

New treatments targeting androgen receptors show promise for drug-resistant prostate cancer.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.