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This collection from the 2021 Manfred Donike Workshop outlines advancements in doping detection, highlighting new test methods and challenges, with a focus on steroidal substances, peptide hormones, and gene doping analysis.

This review examines the complex relationship between polycystic ovary syndrome and its associated skin conditions, highlighting an intricate network influenced by hormonal, genetic, and inflammatory factors but reports no new clinical results.

This review discusses the role of athletic trainers in the medical affirmation and care of transgender and gender-diverse individuals, but it reports no new research findings; the authors emphasize the need for interprofessional collaboration.

This study found that prolonged use of finasteride in women led to altered levels of sex steroids, DNA damage, and increased menstrual bleeding, suggesting adverse health effects without clear benefits for androgenetic alopecia treatment.

This pharmacovigilance study analyzed FAERS data and found that finasteride is more frequently associated with neuropsychiatric reactions like depression and suicide risk, especially in younger men using it for alopecia, compared to dutasteride.

The researchers reported a case of a 51-year-old woman with primary hypothyroidism who developed anaphylaxis to intravenous levothyroxine after being unresponsive to oral formulations, highlighting potential allergic reactions to IV treatments in such patients.

In this preclinical study, PA-011 derived from Periplaneta americana showed significant hair regrowth effects in androgenetic alopecia mouse models by inhibiting inflammation and oxidative stress, activating hair follicle stem cell proliferation, and normalizing skin microbiota, suggesting promise as an AGA treatment.

This study found that administering a supraphysiological dose of testosterone to female rats significantly reduced estrogen and progesterone levels, disrupted sex steroid receptor expression, and interfered with the embryonic implantation window, indicating potential implications for androgen-related endometrial conditions.

This study found that NKB placental mRNA expression was higher in women with PCOS, particularly in pregnancies with female offspring, suggesting its involvement in PCOS-related placental dysfunction.

In this study, Brazilian postmenopausal women reported that menopause significantly deteriorates the quality of their skin, nails, and hair, negatively affecting self-esteem and quality of life, with a need for better understanding of hormone replacement therapy's dermatological effects.

In this study, researchers found that NKB placental mRNA expression was higher in women with PCOS, particularly in pregnancies with female offspring, and that NKB expression varied with fetal gender, suggesting a role in PCOS-related placental dysfunction.

This review discusses the degenerative effects of anabolic-androgenic steroids on the nervous system and reports no new experimental results, aiming to increase public awareness of their health risks.

This review analyzed the use of 5-alpha reductase inhibitors (5ARIs) for treating various dermatological conditions such as androgenetic alopecia, acne, and hirsutism, emphasizing their efficacy and safety profile.

This review article reports recent advancements in understanding, diagnosing, and treating various hair loss conditions, like androgenetic alopecia and alopecia areata, including their genetic factors and new therapeutic options, while also examining the impact of COVID-19 on hair loss.

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

This review explains that dysregulated sebum secretion and composition contribute to acne and impaired skin barriers while highlighting factors like diet and hormones affecting sebaceous activity, and identifies novel molecular targets and model systems for future therapeutic developments.

This review discusses the complex causal relationships between testosterone exposure and various health outcomes, but notes that the studies reviewed show substantial heterogeneity.

This narrative from Vijaya, a breast cancer patient, shares her personal experience with diagnosis, treatment, and support, highlighting the importance of emotional resilience and support groups.

This review discusses the potential impact of volatile organic compound exposure on the onset and progression of autoimmune diseases and reports no new experimental findings.

This study found that finasteride may affect Ca 2+ signalling in human sperm by interacting with the PGE 1 -binding site, but its impact on fertilization requires further investigation.

In this study, topical adenosine 0.75% and minoxidil 5% had similar recovery rates for androgenetic alopecia, but patients reported higher satisfaction with adenosine due to quicker hair loss prevention and new hair appearance.

This study found that specific SNPs in the CYP19A1 gene were associated with Female Pattern Hair Loss in Egyptian women, with altered CYP19A1 gene expression and higher frequencies of related genotypes observed in patients compared to controls.

In this study of a Colombian sample, the researchers found that while sex, alopecia location, and symptoms aligned with global reports, age at presentation, tobacco use, and use of wigs and dyes were different from those noted in other countries.

This review discusses how the hormonal changes of menopause affect skin and hair, highlighting improvements in skin symptoms like dryness and reduced wound healing with estrogen supplementation, and advises healthcare providers to consider broader potential benefits of menopausal hormone therapy when consulting patients.

Male and female mice have different skin thickness, and hormones affect their skin and hair growth differently.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.

This study concluded that Wnt/β-catenin signaling, through Shh and Bmp pathways, is crucial for determining hair follicle fate in embryonic epidermal development.

This study found that the hHa7 gene in hair follicle trichocytes is the first identified to have its expression directly regulated by androgens, suggesting it as a marker for androgen action on hair follicles.

This review discusses the use of hair analysis for examining stress and reproduction hormone levels in wildlife and highlights the need for more comprehensive physiological validations across species.