A Comprehensive Review: The Bidirectional Role of Sebum in Skin Health

    December 2025 in “ Bioengineering ”
    Dan Li, Ziyan Zhou, Xiaobin Yang … Shu Zhang
    Studysummary This review explains that dysregulated sebum secretion and composition contribute to acne and impaired skin barriers while highlighting factors like diet and hormones affecting sebaceous activity, and identifies novel molecular targets and model systems for future therapeutic developments.
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    Research cited in this study 11

    1. 3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration Wound Repair and Regeneration · 2025
    2. Guidelines of Care for the Management of Acne Vulgaris Journal of the American Academy of Dermatology · 2024
    3. Sebaceous Gland Organoid Engineering Burns & Trauma · 2024
    4. Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    5. An Updated Review of the Sebaceous Gland and Its Role in Health and Diseases Part 1: Embryology, Evolution, Structure, and Function of Sebaceous Glands Dermatologic Therapy · 2020
    6. Hormonal Contraceptives And Dermatology American Journal of Clinical Dermatology · 2020
    7. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium Cell · 2019
    8. Transdermal Permeation of Drugs in Various Animal Species Pharmaceutics · 2017
    9. Beyond Acne: Current Aspects of Sebaceous Gland Biology and Function Reviews in Endocrine and Metabolic Disorders · 2016
    10. Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors Stem Cells Translational Medicine · 2016
    11. Acne and Sebaceous Gland Function Clinics in dermatology · 2004