January 2026 in “Journal of Clinical and Investigative Dermatology” This case report describes a father with HOXC13-associated pure hair-nail ectodermal dysplasia, presenting with severe nail dystrophy affecting all digits and notable hypotrichosis or complete alopecia.
November 2025 in “Journal of the European Academy of Dermatology and Venereology” In this study, single-cell RNA sequencing of hair follicle populations from hidradenitis suppurativa patients identified three endotypes, suggesting distinct epithelial-immune interactions that may guide stratified therapeutic approaches.
27 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” 14 citations
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May 1979 in “International Journal of Dermatology” In this study, trichostasis spinulosa was observed in 51 patients with lesions on the nose, where some follicles contained up to 86 hairs each, possibly influenced by endocrine factors and actinic rays.
April 2017 in “Journal of dermatological science” This study reported that human hair follicles containing pluripotent stem cells can differentiate into cardiac muscle and other cells, indicating their potential for future clinical applications in heart and nerve regeneration.
This study found that the long non-coding RNA lnc056 promotes the proliferation of hair follicle stem cells by upregulating TRIP6 expression through interaction with the transcription factor HNRNPUL1, suggesting a potential target for hair loss treatment.
This review of Lawsonia inermis L., or henna, details its bioactive compounds and historical uses in Unani medicine, including treatment for various conditions like ulcers and jaundice, while highlighting its potential for wound healing, hepatoprotective, and other effects, though further research is needed.
4 citations
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March 2000 in “Journal of Investigative Dermatology” The gene for Marie Unna hereditary hypotrichosis is located on chromosome 8p21, near the hairless gene.
June 2018 in “Dermatologic Surgery” This overview discusses the Dermatologic Surgery journal's extensive focus on cosmetic and reconstructive procedures, offering no new research findings.
178 citations
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October 2001 in “Genes & Development” This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.
3 citations
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September 2024 in “Journal of Microbiology and Biotechnology” This study found that human placenta hydrolysate effectively inhibited atopic dermatitis development in stimulated human cells and a mouse model, suggesting its potential as a therapeutic agent for related skin diseases.
36 citations
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July 1996 in “The journal of investigative dermatology/Journal of investigative dermatology” This research reports a new autosomal recessive mutation in mice, 'lanceolate hair', causing generalized alopecia and hair shaft abnormalities, which may serve as a model for Netherton's syndrome in humans.
6 citations
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May 2021 in “Stem Cell Reviews and Reports” This study identified and characterized progenitor cells from equine feet that may play a role in the pathogenesis and recovery of laminitis, suggesting potential therapeutic targets for treatment.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” According to this study, human scalp hair follicles containing pluripotent stem cells demonstrated the ability to differentiate into cardiac muscle cells and other cell types, suggesting potential applications in heart and nerve regeneration.
January 2008 in “HAL (Le Centre pour la Communication Scientifique Directe)” This study identified complex regulatory elements and interactions involving the Hr gene and HR protein that are crucial for hair follicle formation and cycling in mammals.
32 citations
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January 2014 in “Cells tissues organs” This study reports that hair follicle stem cells, termed HAP stem cells, can differentiate into neuronal and glial cells, enhancing nerve repair and locomotor recovery after injury.
14 citations
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December 2009 in “Der Hautarzt”
January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identified a new cis-regulatory element in the mouse Hr gene that influences its expression in skin and brain cells, highlighting a complex molecular network involved in hair follicle formation.
9 citations
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January 1998 in “Studia Anglica Posnaniensia: international review of English Studies” This review discusses the cellular and molecular basis of wound-induced hair neogenesis and its age-related changes, reporting no new clinical results but highlighting areas for future research.
30 citations
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January 2009 in “Nuclear Receptor Signaling” This study identified the Hairless (Hr) gene-encoded protein as a corepressor that plays a crucial role in maintaining skin and hair by regulating epithelial stem cell differentiation and gene expression via chromatin remodeling, which may impact both development and disease.
January 2022 in “Stem cell biology and regenerative medicine” This review discusses the mechanisms of wound-induced hair neogenesis and its similarities with embryonic hair follicle development, but reports no new clinical results.
This genetic study identified a potential interval for the Marie Unna hypotrichosis gene but found no mutations in the nearby hr gene, suggesting its involvement remains unconfirmed.
35 citations
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November 2024 in “Gels” This review discusses hydrogel-forming microneedles for non-invasive drug delivery in dermatology and reports no new clinical results, emphasizing their promise in improving treatment adherence and patient comfort.
12 citations
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May 2016 in “Experimental Dermatology” The researchers concluded that their new reconstructed human epidermis model from plucked hair follicle-derived keratinocytes offers a safer and simpler alternative to traditional skin-derived models for studying epidermal function.
3 citations
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July 2009 in “Experimental and Clinical Endocrinology & Diabetes” In this study, Buserelin nasal spray significantly reduced hirsutism scores and suppressed ovarian steroid secretion in women with non-adrenal hirsutism over six months, with effects lasting post-treatment.
13 citations
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August 1985 in “The Journal of Dermatology” This study identified a monoclonal antibody, HKN-2, that recognizes specific cells in human skin and may indicate a common antigenic determinant between hair and other skin epithelial tissues.
6 citations
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March 1996 in “Journal of Investigative Dermatology” 7 citations
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August 2003 in “Der Hautarzt” 2 citations
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November 2011 in “InTech eBooks” This article reviews how the skin's peripheral stress response system mirrors the central HPA axis, facilitating local homeostasis under stress, but presents no new findings.
6 citations
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May 2012 in “Archives of Dermatological Research” This study reports a novel missense mutation in the HR gene in a 68-year-old Hungarian woman with alopecia universalis and limb deformities, suggesting a need for further research on its role in these conditions.