Stress Hormone and Skin Disease

The document discussed how stress activates neural pathways and the hypothalamic–pituitary–adrenal (HPA) axis, influencing immune responses and skin health. It highlighted the presence of a peripheral stress response system in the skin, similar to the central HPA axis, with corticotropin-releasing hormone (CRH) and its receptors playing a key role. CRH, produced by various skin cells, modulated skin cell activities such as proliferation, differentiation, and inflammation through CRH receptors. The study emphasized CRH's role in stress response, affecting cytokine release and skin homeostasis, with skin mast cells acting as stress sensors.