TLDR HKN-2 antibody targets specific skin and hair cells, showing keratin complexity.
The study involved immunizing BALB/c mice with human hair fibrous proteins and fusing their spleen cells with mouse myeloma cells to produce hybridomas, from which a monoclonal antibody, HKN-2, was selected. HKN-2 was found to recognize specific cells in the epidermis, hair follicle, hair shaft, sebaceous glands, and sweat glands, but not the basal cells of the epidermis, lower hair follicle, hair matrix cells, or secretory cells of sweat glands. The positive reaction to HKN-2 was located on the tonofilaments in the cytoplasm, suggesting a common antigenic determinant between hair and other skin epithelial tissues, indicating complexity in keratin manifestation across different skin tissues.
277 citations
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