Influence of Melatonin on Hair Physiology

December 2009 in “ Der Hautarzt ”

Tobias W. Fischer

Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

We don't know much about this study yet.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

24 / 24 results

research Melatonin as a Major Skin Protectant: From Free Radical Scavenging to DNA Damage Repair

160 citations , July 2008 in “Experimental dermatology”

This review discusses the protective effects and mechanisms of melatonin in skin and suggests potential therapeutic applications in cutaneous medicine, reporting no new clinical findings.

research Melatonin and the Hair Follicle

109 citations , October 2007 in “Journal of pineal research”

This study suggests that melatonin plays a role in hair follicle function by modulating growth and pigmentation, and it may act as a protective agent in active hair growth phases.

research The Impact of Body Site, Topical Melatonin, and Brushing on Hair Regrowth After Clipping Normal Siberian Husky Dogs

17 citations , January 2006 in “Veterinary Dermatology”

This study found that topical melatonin and vigorous brushing did not affect hair regrowth in clipped Siberian Huskies, although lumbosacral hairs grew significantly shorter than lateral thigh hairs.

research Hair Melanocytes as Neuro-Endocrine Sensors—Pigments for Our Imagination

43 citations , October 2005 in “Molecular and cellular endocrinology”

This review discusses how the CRH/POMC systems may regulate human hair follicle pigmentation and highlights the concept of "self-similarity" in melanocortin systems at both local and systemic levels, without presenting new experimental results.

The Role of Melatonin in Neuroectodermal-Mesodermal Interactions: The Hair Follicle Synthesizes Melatonin and Expresses Functional Melatonin Receptors

research The Role of Melatonin in Neuroectodermal-Mesodermal Interactions: The Hair Follicle Synthesizes Melatonin and Expresses Functional Melatonin Receptors

122 citations , July 2005 in “The FASEB journal”

This study found that hair follicles in both mice and humans may serve as an important site for melatonin synthesis and signaling, potentially influencing hair cycle regulation by modulating keratinocyte apoptosis.

research The Cutaneous Serotoninergic/Melatoninergic System: Securing a Place Under the Sun

349 citations , January 2005 in “The FASEB journal”

This review discusses the cutaneous serotoninergic/melatoninergic system's potential role in skin function and resilience against environmental and internal stresses, but does not report new experimental findings.

research On the Role of Melatonin in Skin Physiology and Pathology

222 citations , January 2005 in “Endocrine journal”

This article discusses the potential role of melatonin in protecting skin against stress and maintaining homeostasis, based on its local synthesis and various protective functions, but presents no new clinical results.

research Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production

450 citations , January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article reviews follicular melanogenesis, detailing how melanin synthesis and its regulation in hair follicles depend on a complex interplay of cellular and molecular mechanisms, but reports no new clinical findings.

Melatonin Increases Anagen Hair Rate in Women With Androgenetic Alopecia or Diffuse Alopecia: Results of a Pilot Randomized Controlled Trial

research Melatonin Increases Anagen Hair Rate in Women With Androgenetic Alopecia or Diffuse Alopecia: Results of a Pilot Randomized Controlled Trial

78 citations , February 2004 in “British Journal of Dermatology”

This article reviews the potential impact of melatonin on hair growth, noting its benefits observed in animals, but reports no clinical results in humans to date.

research Characterization of the Serotoninergic System in the C57BL/6 Mouse Skin

84 citations , July 2003 in “European journal of biochemistry”

This study found that mouse skin can produce and metabolize serotonin and N-acetylserotonin, with activity influenced by location, physiological skin status, cell type, and mouse strain.

research HaCaT Cell Proliferation Influenced by Melatonin

28 citations , January 2003 in “Skin pharmacology and physiology”

This study found that melatonin's effect on HaCaT keratinocyte proliferation varied with concentration and incubation time, with no cytotoxic effects observed at suitable concentrations for skin treatment.

research 17α-Estradiol Induces Aromatase Activity in Intact Human Anagen Hair Follicles Ex Vivo

94 citations , August 2002 in “Experimental Dermatology”

This study found that 17α‐estradiol increases aromatase activity in female hair follicles, which may explain its beneficial effects in treating androgenetic alopecia.

research Serotoninergic And Melatoninergic Systems Are Fully Expressed In Human Skin

249 citations , April 2002 in “The FASEB journal”

This study provides evidence that human skin contains genes and enzymes necessary for producing serotonin and melatonin.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.

research Seasonal Fiber Growth Cycles of Ferrets (Mustela Putorius Furo) and Long-Term Effects of Melatonin Treatment

26 citations , August 1995 in “The journal of experimental zoology/Journal of experimental zoology”

This study found that administering melatonin to ferrets can advance the timing of fur growth and reproductive cycles influenced by daylength and hormonal control.

research Growth of Secondary Hair Follicles of the Cashmere Goat In Vitro and Their Response to Prolactin and Melatonin

56 citations , August 1994 in “PubMed”

This study found that prolactin and melatonin both stimulated hair shaft elongation in Cashmere goat hair follicles, with maximum growth observed at specific concentrations, although melatonin reduced follicle viability after 96 hours.

research Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle

161 citations , June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the switch-off of melanogenesis during the hair cycle in C57 BL-6 mice is a gradual and stochastic process starting in mid anagen VI, with specific biochemical markers indicating the transition to catagen.

research Murine Skin as a Target for Melatonin Bioregulation

57 citations , February 1994 in “Experimental dermatology”

This study found that murine skin is a target for melatonin bioregulation, as melatonin affected DNA synthesis and tyrosinase activity in skin organ culture.

research Fiber Growth Initiation in Hair Follicles of Goats Treated with Melatonin

48 citations , September 1993 in “The journal of experimental zoology/Journal of experimental zoology”

In this study, melatonin implants advanced and synchronized spring hair growth in goats by initiating fiber growth earlier than in untreated goats, with associated suppression of normal prolactin rise.

Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

research Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

210 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review discusses the role of intrinsic skin signals, rather than serum signals, in regulating melanin synthesis and hair pigmentation, but reports no new experimental data.