Equine Hoof Stem Progenitor Cells (HPC) CD29+/Nestin+/K15+ – A Novel Dermal/Epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment

This study explores a newly identified population of stem progenitor cells (HPCs) from the coronary corium of equine feet, which could be pivotal in treating laminitis in horses. These HPCs express markers typical of mesenchymal stem cells and demonstrate the ability to expand, differentiate into multiple lineages, and potentially regenerate dermal/epidermal and vascular tissues. The cells also show immunomodulatory functions and are highly proliferative. The research, which involved post-mortem samples from 6 foals, indicates that HPCs have a higher expression of certain keratins compared to adipose-derived stem progenitor cells, suggesting a stronger potential for skin regeneration. Despite limitations due to COVID-19 affecting sample availability, the study concludes that HPCs, with their pro-vasculogenic and immunosuppressive properties, offer a promising target for developing new cell-based therapies for laminitis in horses.