Hair Follicle Stem Cell Fate Supports Distinct Clinical Endotypes in Hidradenitis Suppurativa

    November 2025 in “ Journal of the European Academy of Dermatology and Venereology ”
    Audrey Onfroy, Francette Jean‐Louis, Philippe Le Corvoisier, Fanny Coulpier, Kévin Muret, Éric Bonnet, Raphaele Arrouasse, Caroline Boucle, Salwa Abid‐Essefi, É. Sbidian, Christina Bergqvist, P. Wolkenstein, Véronique Godot, Jean‐François Deleuze, Yves Lévy, Piotr Topilko, Étienne Audureau, Sophie Hüe
    TLDR Different types of hidradenitis suppurativa need specific treatments based on unique skin cell issues.
    The study on hidradenitis suppurativa (HS) reveals new insights into how epithelial-immune interactions contribute to the disease. It suggests that different clinical endotypes of HS are supported by distinct epithelial dysfunctions. This understanding advocates for a stratified therapeutic approach, where treatments are tailored to address specific epithelial abnormalities in patients with HS.
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