Hair Follicle Stem Cell Fate Supports Distinct Clinical Endotypes in Hidradenitis Suppurativa

November 2025 in “ Journal of the European Academy of Dermatology and Venereology ”

Audrey Onfroy, Francette Jean‐Louis, Philippe Le Corvoisier, Fanny Coulpier, Kévin Muret, Éric Bonnet, Raphaele Arrouasse, Caroline Boucle, Salwa Abid‐Essefi, É. Sbidian, Christina Bergqvist, P. Wolkenstein, Véronique Godot, Jean‐François Deleuze, Yves Lévy, Piotr Topilko, Étienne Audureau, Sophie Hüe

Studysummary In this study, single-cell RNA sequencing of hair follicle populations from hidradenitis suppurativa patients identified three endotypes, suggesting distinct epithelial-immune interactions that may guide stratified therapeutic approaches. Our plain-language summary of this paper — not a Tressless recommendation.

The study on hidradenitis suppurativa (HS) reveals new insights into how epithelial-immune interactions contribute to the disease. It suggests that different clinical endotypes of HS are supported by distinct epithelial dysfunctions. This understanding advocates for a stratified therapeutic approach, where treatments are tailored to address specific epithelial abnormalities in patients with HS.

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Research cited in this study

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