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Glossary Histopathological

microscopic examination of tissue to study disease manifestations

Histopathological refers to the microscopic examination of tissue in order to study the manifestations of disease. This process, also known as histopathology, involves analyzing tissue samples under a microscope to identify abnormalities, such as those seen in conditions like alopecia, where hair follicles might show specific patterns of inflammation or damage.

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research Histopathologic Evaluation of Alopecias

90 citations , June 2006 in “The American Journal of Dermatopathology”

This review outlines the classification, histopathologic presentation, and pathogenetic concepts of scarring and nonscarring alopecias, reporting no new clinical results and emphasizing the need for clinicopathologic correlation.

research Histopathological Study on Collagen in Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei)

7 citations , May 2023 in “Animals”

This study observed that Fraser’s dolphins exhibit remarkable skin healing abilities, with type I collagen prevalent in normal skin and type III collagen emerging during early wound healing before returning to normal configuration, suggesting insights for human clinical wound management.

Assessing Dihydrotestosterone-Induced Skin Alterations in C57BL/6 Mice: Implications for Androgenetic Alopecia Through High-Resolution Ultrasound Imaging

research Assessing Dihydrotestosterone-Induced Skin Alterations in C57BL/6 Mice: Implications for Androgenetic Alopecia through High-Resolution Ultrasound Imaging

January 2026 in “Frontiers in biomedical technologies”

In this study, high-resolution ultrasound imaging revealed that DHT administration in male C57BL/6 mice leads to increased epidermal and dermal thicknesses and decreased skin elasticity, simulating structural changes associated with Androgenetic Alopecia.

research Lipidized Fibrous Histiocytoma: Differential Diagnosis from Juvenile Xanthogranuloma

3 citations , January 2019 in “Annals of Dermatology”

The study concluded that careful examination is key to differentiate between lipidized fibrous histiocytoma and juvenile xanthogranuloma.

Condylomata Acuminata of HIV-Positive Men May Harbor Focal Areas of Dysplasia: Relevant Implications for the Management of Human Papillomavirus-Induced Disease in High-Risk Patients

research Condylomata acuminata of HIV-positive men may harbour focal areas of dysplasia: relevant implications for the management of human papillomavirus-induced disease in high-risk patients

3 citations , September 2016 in “British Journal of Dermatology”

Warts in HIV-positive men can have serious abnormal cell growth, needing careful analysis and treatment to prevent cancer.

research Cutaneous Granular Cell Tumor with Overlying Hypertrichosis in an Adult: A Rare Case Report

March 2026 in “Dermatopathology”

In this case report, a rare instance of a primary cutaneous granular cell tumor with prominent overlying terminal hair growth in an adult is described, highlighting the importance of recognizing atypical presentations to accurately diagnose similar uncommon neoplasms.

research Canities Subita after Extreme Trauma Showing Positive Staining for Anti-PD-L1 Antibodies: A New Clue into Etiopathogenesis?

4 citations , July 2021 in “Skin Appendage Disorders”

This case report describes canities subita, characterized by sudden hair whitening without hair loss, in a patient following a stressful event, suggesting an immune system involvement.

research Expression of COX-2 and Bcl-2 in 50 patients of Lichen Planus

April 2020 in “International journal of clinical and diagnostic pathology”

This study examined Bcl-2 and COX-2 expression in Lichen Planus cases, highlighting their roles in apoptosis protection and inflammation, with results analyzed statistically.

research Alopecia areata with lymphocytic mural folliculitis affecting the isthmus in a thoroughbred mare

14 citations , August 2004 in “Veterinary Dermatology”

In this study, a thoroughbred mare exhibited a unique case of alopecia areata with lymphocytic infiltration at both the bulbar and isthmic levels of hair follicles.

research Localized Primary Cutaneous Nodular Amyloidosis in a Patient With Paraproteinemia

3 citations , March 2012 in “Actas Dermo-Sifiliográficas”

An elderly man with skin amyloidosis and abnormal blood proteins was monitored without finding widespread disease after 18 months.

research Mechanisms of Dermatophyte Invasion on New Zealand Rabbit Skin Models

1 citations , January 2020 in “E3S web of conferences”

In this study, an infection model using rabbits was developed for dermatophytosis by inoculating macroconidia of Microsporum species, showing that direct intradermal application effectively progressed to the skin invasion phase and highlighted the correlation between severity of symptoms and duration post-inoculation.

research Folliculotropic non-alopecic secondary syphilis

6 citations , September 2011 in “Journal of the American Academy of Dermatology”

This report describes a case of secondary syphilis with an unusual folliculocentric papular eruption in an HIV-positive patient, underlining the diagnostic challenges and importance of biopsy with treponemal staining in such cases.

research SUBEPIDERMAL CALCIFIED NODULE OF THE EAR IN A CHILD WITH HAIR FOLLICLE NEVUS

19 citations , July 1994 in “International Journal of Dermatology”

This case report describes a 9-year-old Korean boy with a calcified nodule on his earlobe, confirmed by histopathologic examination and Von Kossa staining.

research Oestrogen receptor evaluation in Pomeranian dogs with hair cycle arrest (alopecia X) on melatonin supplementation

20 citations , July 2006 in “Veterinary dermatology”

This study found that hair regrowth in Pomeranians with hair cycle arrest treated with melatonin was not associated with a change in oestrogen receptor-α staining.

research Comparıson of the effect of the autogenıc and xenogenıc use of platelet-rıch plasma on rabbıt chondrocutaneous composıte graft survıval

January 2023 in “Journal of Plastic Surgery and Hand Surgery”

This study observed that both autogenic and xenogenic PRP improved graft viability in rabbits compared to control, with autogenic PRP showing better histopathological results.

research Primary Cutaneous Rhabdoid Squamous Cell Carcinoma: A Case Report and Review of Molecular Features

1 citations , November 2024 in “Cureus”

This case report describes a rare aggressive variant of squamous cell carcinoma on the scalp of a non-immunosuppressed older male, highlighting its high biological risk for metastasis and poor outcomes.

research Clinicopathologic study of 90 cases of trichofolliculoma

19 citations , September 2016 in “Journal of the European Academy of Dermatology and Venereology”

This article is a letter discussing a clinicopathologic study of 90 cases of trichofolliculoma and reports no new results.

research Keratoacanthoma of the lip: A case report with emphasis on histogenesis

8 citations , January 2017 in “Journal of Oral and Maxillofacial Pathology”

This report explores the potential cellular origins of keratoacanthoma lesions on the oral mucosa, noting that it reports no new results.

research Steroid Cell Tumor Without Virilization

October 2016 in “Journal of Case Reports”

This study reports a case of an ovarian steroid cell tumor with malignant potential, presenting unusually with osteopenia and low weight instead of the expected virilizing symptoms.

research Histopathological and Immunohistochemical Study of Trichoblastoma in the Rabbit

9 citations , August 2017 in “Journal of comparative pathology”

This study suggests that uncontrolled embryonic trichogenesis may play a role in the development of trichoblastoma in rabbits.

Histopathological and Topical Immunological Changes in Alopecia

research Histopathologycal and topical immunologycal changes in alopeciae

September 1998 in “Journal of the European Academy of Dermatology and Venereology”

This article reviews the role of androgen in male pattern hair loss and its impact on hair follicle miniaturization, but it does not present new research findings.

research Elastin staining patterns in primary cicatricial alopecia

30 citations , November 2013 in “Journal of The American Academy of Dermatology”

This study reported that patterns of fibrosis identified through elastin staining may help distinguish specific forms of primary cicatricial alopecia in biopsy specimens, with certain patterns suggesting particular diagnoses.

research The utility of elastic Verhoeff-Van Gieson staining in dermatopathology

38 citations , December 2012 in “Journal of Cutaneous Pathology”

This review discusses the significance of elastic tissue staining in dermatopathology, particularly for diagnosing primary elastic tissue disorders and other skin conditions, but reports no new clinical results.

research Primary scalp alopecia: new histopathological tools, new concepts and a practical guide to diagnosis

14 citations , September 2016 in “Journal of Cutaneous Pathology”

This review discusses the classification and diagnosis of primary scalp alopecia, focusing on scarring and non-scarring types, and reports no new clinical results; it emphasizes simplified diagnostic pathways and tissue processing techniques.

Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

research Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

10 citations , January 2010 in “Acta Histochemica Et Cytochemica”

This study found that patients with alopecia areata and androgenetic alopecia showed increased c-kit expression and decreased Ki-67 expression in hair follicle cells compared to controls, suggesting a possible feedback mechanism involving stem cell factor signaling.

Histopathological Investigation of Clinically Non-Affected Perilesional Scalp in Alopecias Detected Unexpected Spread of Disease Activities

research Histopathological investigation of clinically non‐affected perilesional scalp in alopecias detected unexpected spread of disease activities

9 citations , August 2014 in “The Journal of Dermatology”

This study found that clinically non-affected perilesional scalp in Japanese alopecia patients often showed microscopic abnormalities, which may help in assessing the spread of disease activities.

Clinical And Histopathological Findings In Patients With Follicular Dermatoses: All Skin Diseases Start In The Hair Follicles As A New Hypothesis

research Clinical and Histopathological Findings in Patients with Follicular Dermatoses: All Skin Diseases Starts in the Hair Follicles as New Hypothesis

2 citations , January 2020 in “American Journal of Clinical Research and Reviews”

This study suggests that hair follicles may be the primary target in the onset of various skin diseases, potentially spreading to affect the surrounding epidermis.

research Histopathological Evaluation of Human Placental Extract as a Direct Pulp-Capping Material in Dogs' Teeth

1 citations , June 2024 in “European Journal of Dentistry”

This study found that human placenta extract may be a promising pulp-capping material, causing less intense chronic inflammation and thicker dentine bridge formation compared to mineral trioxide aggregate in dogs' teeth.

Histopathological Findings of Uncomplicated Hair Transplant for Male Androgenetic Alopecia: Can Lichen Planopilaris Features Be Present?

research Histopathological Findings of Uncomplicated Hair Transplant for Male Androgenetic Alopecia: Can Lichen Planopilaris Features Be Present?

1 citations , January 2020 in “Skin appendage disorders”

This study questions whether lymphocytic infiltrate and fibrosis observed after uncomplicated hair transplants might be expected without indicating lichen planopilaris.

Histopathological Characteristics May Not Be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appendages Originating from Hair Follicle

research Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

1 citations , September 2011 in “UHOD : Uluslararası hematoloji - onkoloji dergisi”

This study found no significant differences in age, sex, or histopathological characteristics for differentiating basal cell carcinoma from benign tumors of cutaneous appendages, complicating diagnosis.