Keratoacanthoma of the Lip: A Case Report with Emphasis on Histogenesis

Keratoacanthoma (KA) is a common benign cutaneous lesion that occasionally appears on mucous membranes, such as the lip. This case report focused on a 45-year-old female with a KA on her lower lip, highlighting its histogenesis. The study suggested that KA of the oral mucosa likely originates from ectopic sebaceous glands rather than hair follicles, as indicated by negative PAS staining for glycogen granules. KA is often confused with squamous cell carcinoma (SCC) due to similar clinical features, but histopathology can differentiate the two. Complete excision is recommended for treatment, as it promotes healing without scarring and allows for thorough histopathological evaluation.