Histopathological Study on Collagen in Full-Thickness Wound Healing in Fraser's Dolphins (Lagenodelphis hosei)

    May 2023 in “ Animals
    Chen-Yi Su, Tzu‐Yu Liu, Hao‐Ven Wang, Wei‐Cheng Yang
    TLDR Fraser's dolphins heal wounds exceptionally well, with their skin's collagen returning to normal after injury.
    Fraser’s dolphins exhibit exceptional wound healing abilities, with their skin's collagen structure returning to normal after injury. This study used Herovici’s, trichrome, and immunofluorescence staining to analyze collagen in both normal and wounded skin of these dolphins. It was found that type I collagen predominates in normal skin, while type III collagen appears early in the wound healing process and type I collagen increases as the wound matures. Initially, the collagen forms a transient hypertrophic-like scar, but eventually, it reorganizes to its normal configuration. The dolphins' ability to remove excessive collagen could offer valuable insights for improving clinical wound management.
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