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In this study, embryonic skin fibroblasts from day E17.5 and postnatal day P5, but not E14.5, effectively supported hair follicle formation, indicating distinct developmental states and differentiation capacities.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

This document details the usage policy for full-text reproduction from Durham E-Theses, providing guidelines for personal, educational, and non-commercial purposes without altering the text.

In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.

This study found that nestin-driven GFP labels blood vessels originating from hair follicles in mice, which could be used to study early events in skin angiogenesis and for antiangiogenesis drug screening.

This study found that deleting the Hes1 gene disrupts hair regeneration by delaying anagen initiation and shortening the anagen phase, suggesting it's crucial for maintaining hair cycle homeostasis.

Pigs are a good model for studying human hair growth and disorders.

This study proposes a model describing the transformation process from living to dead cells during early hair formation, highlighting the stepwise degradation of cellular functions.

This study found that matrix progenitor cell differentiation in hair growth has distinct early and late phases, and generated a mouse model to explore the hair follicle's role in harlequin ichthyosis.

This study in mice found that overexpressing Sonic Hedgehog in basal cells caused skin anomalies and a lack of certain hair fibers, underscoring its key role in hair follicle development.

This review discusses recent research on the cell sources and signaling pathways involved in wound-induced hair follicle neogenesis, noting its complexity and association with immune responses, but reports no new experimental findings.

This study found that cell spheres formed from mesenchymal cells in newborn mouse skin showed increased expression of genes associated with hair follicle regeneration, though marker distribution varied and requires further investigation.

This study mapped the development of the human pilosebaceous unit in prenatal scalp skin using multi-modal analysis, finding that epithelial-mesenchymal interactions guide cellular fate and validated tissue-patterning through a hair-bearing skin organoid model.

In this review, researchers explored how various cell types and molecular mechanisms contribute to wound-induced hair follicle neogenesis, highlighting its potential as a therapeutic approach for regenerating hair follicles and minimizing scar formation after injury.

The researchers identified differences in gene expression between fetal and adult dermal papilla cells that could explain fetal cells' ability to regenerate hair follicles, while adult cells lack this capacity.

This study found that inhibiting apoptosis during hair follicle regression in mice disrupted hair regeneration, causing delays and alterations in stem cell niche architecture and associated tissue remodeling processes.

This study suggests that heparan sulfate is crucial for regulating hair follicle formation, cycling, and gland morphogenesis, with its ablation leading to continuous hair growth and increased gland activity in mice.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

This study revealed key cellular dynamics and interactions during early embryonic mouse skin development, highlighting complex transitions from precursor states to diverse multilayered structures.

In this study, transient transfection of the HIF-1α gene into fibroblasts led to increased VEGF expression, which may enhance the growth and anagen phase of human hair follicles in vitro.

In this study, researchers mapped gene expression in developing hair follicles to reveal unknown cell populations and markers, suggesting early establishment of cell fates in hair placodes.

This study reported that Sonic hedgehog signaling is crucial for hair follicle development, with its expression being significantly induced in normal embryonic hair germs but inhibited in certain experimental models.

In this study, researchers discovered that HEY2+ dermal papilla cells exhibit stemness and contribute to dermal regeneration during wound healing, as shown by the expression of a reporter gene in regenerated dermal cells of tamoxifen-induced transgenic mice.

This study found that human induced pluripotent stem cells differentiated precisely to express certain markers during a specific window could enable successful hair follicle generation when transplanted.

This review discusses recent advances in understanding hair follicle stem cell dynamics and interactions, but it reports no new experimental findings.

This review examines recent research on hair follicle stem cells, focusing on their maintenance, differentiation, and the potential for new follicle generation, but it reports no new experimental results.

This study found that human progenitor keratinocytes form unique complements of enhancers and super-enhancers during differentiation and migration, influencing gene expression and skin disease variant enrichment.