July 2025 in “Frontiers in Animal Science” This editorial discusses the need for continued research on animal fibers, highlighting recent advances in the field and the impact of economic factors favoring meat over fiber production on research volume.
This review reports that exosome-based therapies, coupled with nanotechnology and AI, show promise in aesthetic medicine, notably in skin rejuvenation and hair restoration, but large-scale trials and clearer regulatory frameworks are needed for effective clinical adoption.
The systematic review reported promising outcomes for stem cell-enriched treatments in aesthetic medicine, such as improved skin rejuvenation, hair restoration, and scar revision. However, challenges like protocol variability and regulatory issues must be addressed to ensure effective and safe clinical applications.
January 2025 in “Journal of Aesthetic Nursing” This review discusses the expanding role of microneedling in dermatology, highlighting its enhanced effectiveness when combined with other treatments like minoxidil, platelet-rich plasma, and exosomes, but reports no clinical results.
January 2025 in “Dialnet (Universidad de la Rioja)” In this case study, a 14-year-old male with treatment-resistant diffuse alopecia areata experienced complete hair regrowth after three monthly sessions of microneedling combined with triamcinolone, dutasteride, and synthetic exosomes, suggesting this therapy might enhance outcomes in refractory cases.
This study reviewed various methods and techniques aimed at overcoming limitations in culturing human hair follicles, specifically focusing on restoring the inductivity of hair follicle cells for successful hair regeneration.
December 2024 in “Biomaterials Research” This study demonstrated that exosomes from human hair follicle mesenchymal stem cells can enhance collagen production, promote cell proliferation and migration in human dermal fibroblasts, and reverse signs of UV-induced skin aging in mice, potentially via a miR-125b-5p/TGF-β1/Smad signaling pathway.
December 2024 in “Research Square (Research Square)” In this phase I/II clinical trial, placenta-derived mesenchymal stem cell exosome therapy significantly improved hair density and diameter, and reduced hair loss in patients with androgenetic alopecia, though further large-scale studies are needed to confirm these results and investigate the underlying molecular mechanisms.
December 2024 in “American Journal of Biomedical Science & Research” This review explores the critical role of stem cells in body maintenance and their potential in regenerative medicine, highlighting their impact on aging and rare diseases and examining their influence on various body systems and the therapeutic potential of exosomes.
November 2024 in “Journal of Cosmetic Dermatology” Regenerative medicine is effective and safe for treating vitiligo.
October 2024 in “Biology” This review discusses the role of dermal papilla cells in hair follicle formation and their potential use in cell therapy for hair loss, but reports no new research findings.
August 2024 in “International Journal of Basic & Clinical Pharmacology” This literature review examined research on hair follicle biology and hair loss treatments, highlighting the potential of secretome-based therapies, which may enhance hair regeneration and address limitations of treatments like minoxidil and finasteride.
August 2024 in “Stem Cell Research & Therapy” This review discusses current and emerging therapies for androgenetic alopecia, emphasizing regenerative treatments and nanotechnology advancements, but it reports no new clinical results.
July 2024 in “Journal of Dermatology Research Reviews & Reports” This study reviews the potential of stem cell-based therapies, including transplants and exosome treatments, to reactivate hair follicle stem cells and promote hair growth in individuals experiencing pattern hair loss.
July 2024 in “Journal Of Stem Cell Research” In this review, the authors highlight the crucial role of mesenchymal stem cells in dermatologic therapies, noting their potential to enhance skin structure and appearance through regenerative mechanisms like inflammation induction, angiogenesis, and recruitment of tissue-specific progenitors.
July 2024 in “Gene & Protein in Disease” This review discusses the potential of exosome-based therapies in dermatology, highlighting their ability to treat conditions like alopecia and accelerate wound healing, though further research is needed to understand long-term safety and develop standardized clinical protocols.
This study found that germinated hemp seeds extract and exosomes from their calli can prevent androgenetic alopecia by modulating genetic, cellular, and immune responses in hair follicle dermal papilla stem cells and CD8+ T cells, with exosomes being more effective.
May 2024 in “International Society of Hair Restoration Surgery” This paper describes various emerging regenerative therapies for hair loss, such as platelet-rich plasma, exosomes, and low-level laser therapy, but it doesn't provide results or conclusions about their efficacy.
This article provides a detailed analysis of exosome therapy as a novel treatment for hair loss, discussing its potential benefits, limitations, and the importance of standardized research reporting as human research remains limited.
January 2024 in “Journal of tissue engineering” In this study, researchers used a human skin organoid model to show that solar UV exposure damages hair follicles and skin, while exosomes from mesenchymal stem cells reduced inflammation and supported hair follicle regeneration.
January 2024 in “Surgical & Cosmetic Dermatology” This review discusses recent research on exosomes' role in dermatology, highlighting their involvement in skin diseases and rejuvenation and exploring therapeutic possibilities in these areas.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, exosome-like nanoparticles derived from rose stem cell culture were found to enhance skin quality by increasing collagen production, reducing melanin and inflammation, and promoting cell migration in vitro, suggesting potential aesthetic applications.
This review discusses the use of umbilical cord blood in regenerative medicine, focusing on collection, banking processes, and ethical considerations, without presenting new clinical results.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that TLR3 activation in human keratinocytes enhances exosome biosynthesis and expression of hair follicle stem cell markers, suggesting a potential mechanism for tissue regeneration.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that early-stage dermal papilla cell-derived exosomes may enhance adipose stem cells' hair inductive abilities through specific miRNAs.
September 2022 in “Institutional Repositories DataBase (IRDB)” 3D-oxy exosomes may significantly boost hair growth, offering new treatment options for hair loss.
March 2022 in “Research Square (Research Square)” This study reported that pelage hair follicle mesenchymal stem cells isolated from mice using Ficoll Density Gradient Sedimentation can be obtained in large numbers and may promote hair growth via exosome secretion.
January 2022 in “Journal of St. Marianna University” This study investigated how secretions from cultured human hair follicle-derived keratinocytes affect gene expression in human follicle dermal papilla cells to understand their signaling interactions.
January 2022 in “Biocell” This review outlines the potential of mesenchymal stem cells and their derivatives as emerging therapies for atopic dermatitis, but reports no new clinical results; the authors highlight the need for further investigation.
April 2019 in “C&EN global enterprise” In this study, a patch with microneedles regrew hair in shaved mice within six days, suggesting potential for treating hair loss in humans.