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In this study, researchers developed a novel 3D bio-printed skin scaffold using exosomes from liver cells, which enhanced wound healing by promoting cell growth, angiogenesis, and reducing inflammation in large skin injuries, suggesting potential applications in treating chronic skin conditions.

This study found that plucked hair follicles can serve as a practical and scalable source for regenerative medicine, as researchers successfully isolated and expanded keratinocytes and mesenchymal stem cells for potential cell-based and cell-free therapies, demonstrating significant wound-healing bioactivity in vitro.

In this study, exosome-loaded hydrogels derived from skin precursor cells significantly improved wound healing in diabetic rats by enhancing angiogenesis, reducing inflammation, and promoting tissue repair.

This literature review examines current anti-aging therapies, focusing on innovative genetic cosmeceuticals enhanced by nanotechnology, which offer targeted and minimally invasive treatment options by effectively delivering anti-ageing genetic elements to skin cells and potentially improving skin health through reduced oxidative stress.

This study developed a novel regenerative platform using nanozyme-enabled materials combined with exosomes and laser stimulation to enhance wound healing in a mouse model, which more effectively regulated reactive oxygen species and improved early angiogenesis and collagen organization compared to conventional methods.

This systematic literature review found that exosome and PRP therapies show promise as effective, minimally invasive options for treating androgenetic alopecia, with clinical benefits potentially superior to or complementary to minoxidil, although standardization and larger clinical trials are needed to confirm long-term safety and efficacy.

This review focuses on the role of exosomes in diagnosing and treating various dermatological diseases, emphasizing their potential to promote skin regeneration, improve cosmetic outcomes, and modulate immune-related conditions, with the anticipation of expanded future applications.

This study found that mesenchymal stem cells mainly promote skin regeneration and delay aging through paracrine activity, releasing growth factors and cytokines that protect against oxidative stress and stimulate healing.

This review provides a comprehensive look at injectable treatments like PRP, stem cells, and exosomes for hair regrowth, highlighting their potential to minimize systemic and localized side effects associated with conventional medications, and improve patient care by stimulating natural hair growth.

This study found that SPARC-overexpressing adipose-derived mesenchymal stem cells significantly improved various aspects of skin wound healing in dogs, including re-epithelialization, collagen deposition, and angiogenesis, showing promise for enhancing treatment effectiveness under different physiological and pathological conditions.

This study reviewed treatments and findings related to male androgenetic alopecia, noting that topical minoxidil and oral finasteride are effective for slowing hair loss, while newer interventions like PRP and microneedling show promise.

This review discusses the epidemiology, pathophysiology, diagnosis, and management of male androgenetic alopecia, noting that combination treatments, including FDA-approved and emerging therapies, may improve outcomes without added side effects.

This narrative review examines advancements in regenerative aesthetic medicine, focusing on injectable modalities like PRP, polynucleotides, and exosomes, but highlights the need for more robust evidence and standardization in clinical applications.

This study observed that while hair density generally increased after PRP-based treatments for nonscarring alopecia, the extent of improvement and associated biomarker changes varied widely among individuals.

In this case study, a 14-year-old boy with treatment-resistant diffuse alopecia areata achieved complete hair regrowth following three monthly sessions of microneedling combined with injections of triamcinolone, dutasteride, and synthetic exosomes, suggesting that exosome-based therapy could be a promising alternative for managing refractory autoimmune alopecia.

This study reports on a 14-year-old male with refractory diffuse alopecia areata who achieved full hair density restoration after three monthly sessions of microneedling combined with triamcinolone, dutasteride, and synthetic exosome treatment, highlighting exosomes' potential for enhancing traditional therapies in autoimmune hair loss cases.

This study highlights emerging regenerative strategies, such as stem cell-derived therapies and machine learning tools, that may advance hair loss treatment beyond traditional methods by promoting follicle regeneration and offering personalized care.

This article provides an educational overview of emerging regenerative technologies for hair growth, highlighting potential therapies like mesenchymal stem cells and platelet-rich plasma while noting their current experimental status and the need for standardized protocols and long-term safety data.

This bibliometric analysis reported a significant increase in publications on hair loss treatments since 2001, highlighting new focuses on non-invasive regenerative therapies like platelet-rich plasma, microneedling, and JAK inhibitors, but emphasized the need for further high-quality clinical trials to confirm their effectiveness.

This study bibliometrically evaluated 5741 articles on PRP from 1980 to 2024, highlighting Türkiye's contribution and identifying prominent research areas such as orthopedics and wound healing.

In this systematic review, researchers found that nanotopical systems like nanoparticles and liposomes significantly improved hair density, thickness, and follicular regeneration markers in alopecia treatment, sometimes surpassing traditional therapies like topical minoxidil, though methodological limitations remain such as insufficient long-term clinical trials.

This review suggests that mesenchymal stem cells and exosomes may be effective in regenerating hair follicles for treating androgenic alopecia, but more research on their mechanisms and efficacy is necessary.

In this preprint, an integrative regenerative protocol involving microneedling, plant-derived exosomes, and other therapies was used to treat androgenetic alopecia in an elderly woman, resulting in improved hair density and scalp coverage.

This preprint reports meaningful improvements in hair density and scalp coverage in an elderly female with androgenetic alopecia treated through an integrative regenerative protocol, involving microneedling and plant-derived exosomes, among other non-pharmacological interventions focusing on cellular senescence pathways.

In this review, recent innovations in hair transplantation, such as AI-assisted graft selection, robotic systems, stem cell therapy, and advanced drug delivery techniques, are reported to enhance hair density and thickness for more natural results and higher patient satisfaction by addressing limitations of traditional methods.

This review found that adipose-derived stem cells and stromal vascular fraction have robust clinical benefits in aesthetic surgery, particularly in facial rejuvenation, scar treatment, and volumetric restoration, with favorable safety profiles.

This study highlights exosome-based therapies as promising treatments for androgenetic alopecia, detailing protocol development, quality control measures, and clinical application examples, with mesenchymal stem cell-derived exosomes improving hair density in a case study without adverse effects.

This study observed that exosomes from adipose stem cells and dermal papilla cells altered the immune environment in hair follicles, promoting hair regrowth in mouse models and human follicle cultures.

This review reports significant advancements in plastic surgery using stem cell therapies for aesthetic and reconstructive applications, including grafting and wound healing, though it underscores the need for continued research to address regulatory, ethical, and standardization issues.

This study found that exosomes from human umbilical cord stem cells, pretreated with lithium chloride, significantly enhance hair regeneration in mice by activating the Wnt signaling pathway through miR-146a-5p.