Exosome-Mediated Immunomodulation in Hair Regeneration: From Bench to Bedside

    November 2025 in “ Trends in Immunotherapy ”
    Wei Xinyu, Muhamed T. Osman
    TLDR Exosomes from certain cells can improve hair regrowth by changing the immune response.
    The study investigates the use of exosomes from adipose stem cells and dermal papilla cells for hair regeneration, demonstrating in mouse models and ex vivo human follicle cultures that these exosomes can modulate the immune environment. They increase regulatory T cells and M2 macrophages while reducing harmful CD8 T cells, leading to decreased pro-inflammatory cytokines and increased immunoregulatory factors. This immune reprogramming correlates with improved hair regrowth, indicating potential for targeted immunotherapies in treating alopecia, though further clinical studies are needed for confirmation.
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