TLDR Exosomes show promise for treating skin conditions and improving cosmetic skin health.
This review explores the potential of exosomes as a non-cellular therapeutic option in dermatology and cosmetology. Exosomes are nanovesicles that facilitate intercellular communication and carry bioactive substances, showing promise in modulating cell microenvironments, regulating gene expression, and inducing cell differentiation. They have been used to promote tissue regeneration in skin wounds and treat conditions like systemic lupus erythematosus, psoriasis, atopic dermatitis, systemic sclerosis, pigment regulation, vitiligo, and hair growth. Cosmetically, exosomes help reduce wrinkles, improve skin texture and moisture, enhance elasticity, and mitigate UV-induced inflammation and cellular damage. The review suggests further research to expand their applications.
March 2024 in “Indian Journal of Dermatology/Indian journal of dermatology” Exosomes could be key in treating skin conditions and healing wounds.
6 citations
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April 2023 in “Cosmetics” Exosomes could be effective for improving skin health and treating skin diseases.
72 citations
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January 2023 in “International Journal of Biological Sciences” Engineered exosomes show promise for improving wound healing but face challenges in clinical use.
4 citations
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December 2022 in “Frontiers in Bioengineering and Biotechnology” Exosomes show promise for improving wound healing, reducing aging signs, preventing hair loss, and lightening skin but require more research and better production methods.
106 citations
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August 2021 in “Pharmaceuticals” Extracellular vesicles help heal skin wounds and could be used for better treatments.
47 citations
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February 2021 in “Pharmacological research” Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.
192 citations
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April 2019 in “ACS nano” A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.
87 citations
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April 2018 in “Biochemical and Biophysical Research Communications” Exosomes from dermal papilla cells can help grow hair and might treat hair loss.
135 citations
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December 2015 in “Expert Opinion on Biological Therapy” Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.
1 citations
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October 2025 in “International Journal of Nanomedicine” Exosomes could revolutionize skin disease treatment and healing.
September 2025 in “Frontiers in Cell and Developmental Biology” TCM-derived nanovesicles show promise for wound healing and skin regeneration but need more research.
3 citations
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February 2023 in “International Journal of Molecular Sciences” Autologous Platelet and Extracellular Vesicle-Rich Plasma (PVRP) has potential in enhancing tissue regeneration and improving hair conditions, but its effectiveness varies due to individual differences.
October 2025 in “Gene Expression” Exosome therapy could be a promising new way to treat hair loss.