Female Androgenetic Alopecia in Elderly Patient: Case Report with Integrative Regenerative Protocol and Senescence Modulation
December 2025
in “
Zenodo (CERN European Organization for Nuclear Research)
”
androgenetic alopecia microneedling plant-derived exosomes biomimetic growth factors topical amino acids B-complex vitamins vacuotherapy senomorphic supplementation mitochondrial function oxidative stress chronic low-grade inflammation follicular miniaturization scalp coverage follicular microenvironment cellular senescence hair loss exosomes growth factors amino acids B vitamins vacuum therapy anti-aging supplements oxidative stress reduction inflammation management
Studysummary This preprint reports meaningful improvements in hair density and scalp coverage in an elderly female with androgenetic alopecia treated through an integrative regenerative protocol, involving microneedling and plant-derived exosomes, among other non-pharmacological interventions focusing on cellular senescence pathways.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This preprint details a case report of an elderly female patient with androgenetic alopecia treated using an integrative regenerative protocol. The treatment included microneedling, plant-derived exosomes, biomimetic growth factors, topical amino acids and B-complex vitamins, vacuotherapy, and systemic senomorphic supplementation. These interventions targeted mitochondrial function, oxidative stress, and chronic low-grade inflammation. The results showed significant improvements in hair density, follicular miniaturization, and scalp coverage, highlighting the importance of addressing the follicular microenvironment and cellular senescence in managing androgenetic alopecia non-pharmacologically.
