Exosomes And Platelet-Rich Plasma As New Regenerative Therapies In Alopecia: A Systematic Literature Review

    Carolina Pimentel Fogaça de Souza, Vitória Eduarda de Souza Moraes, MARIA JULIA BARROS HOLAK, Phc Oliveira, Ana Clara Meneses Ribeiro, Fátima Lúcia Cartaxo Machado de Castro
    From the encyclopedia
    Exosomes →

    Microscopic delivery system that sends growth-promoting signals to hair follicles

    Platelet-Rich Plasma →

    growth factors taken from your blood and injected into your scalp to stimulate hair

    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

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    Studysummary This systematic literature review found that exosome and PRP therapies show promise as effective, minimally invasive options for treating androgenetic alopecia, with clinical benefits potentially superior to or complementary to minoxidil, although standardization and larger clinical trials are needed to confirm long-term safety and efficacy.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    Recent studies on regenerative therapies for androgenetic alopecia (AAG) show significant progress in understanding and effectiveness of approaches like exosomes, platelet-rich plasma (PRP), and cellular therapies. This systematic literature review aimed to analyze recent scientific evidence on regenerative therapies using exosomes, PRP, and minoxidil for AAG treatment. Conducted in August 2025, the research identified 63 articles, with 8 meeting the inclusion criteria for analysis. The findings highlight the potential of exosome and PRP therapies as effective and minimally invasive alternatives for managing AAG, offering superior or complementary clinical benefits compared to minoxidil, with better tolerability and broader biological effects. However, despite encouraging results, there is a consensus on the need for standardized preparation, dosage, and application protocols, as well as larger-scale and long-term clinical trials to confirm the efficacy and safety of these treatments.
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