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Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Kawasaki Disease is rare and often missed in adults, who show different symptoms than children, and may benefit from early treatment.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

The circadian clock influences the behavior and regeneration of stem cells in the body.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Shen-Min, a hair growth supplement, likely caused acute hepatitis in a woman, improving after she stopped taking it.

PCOS is a common hormonal disorder in women, treated with lifestyle changes and medications like hormonal contraceptives and metformin.

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

Menopause and aging can affect women's quality of life and sexuality, but hormone therapies may help alleviate these issues.

Different types of fibroblasts play various roles in both healthy and diseased tissues, and understanding them better could improve treatments for fibrotic diseases.

Researchers created rat liver stem cells that could help repair liver failure in rats and may be useful for studying human liver diseases.

Jojoba oil is highly valued for its diverse medicinal and industrial uses.

Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Researchers isolated a new type of stem cell from mouse skin that can renew itself and turn into multiple cell types.

Two patients with porphyria cutanea tarda experienced their grey hair turning dark again.

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

Fibromodulin treatment helps reduce scarring and improves wound healing by making it more like fetal healing.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.

Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

Teriflunomide is effective and generally safe for treating relapsing-remitting multiple sclerosis.

Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.

ARL15 is important for fat cell development and the release of the hormone adiponectin.

Finasteride worsens erectile dysfunction and lowers testosterone in men with enlarged prostates, unlike tamsulosin.