Tissue Fibrosis Associated Depletion of Lipid-Filled Cells

    March 2024 in “ Experimental Dermatology ”
    Anna R. Jussila, Brian Zhang, Sakin Kirti, Radhika P. Atit
    TLDR Fibrosis causes loss of important fat cells, affecting tissue function.
    The document discusses the phenomenon of fibrotic lipodystrophy, where fibrosis involves not only excessive extracellular matrix deposition but also the loss of lipid-filled cells, which are crucial for tissue function and integrity in organs like the skin and lungs. The depletion of these cells during fibrogenesis affects tissue function and can alter ECM composition and stability. The review highlights emerging common mechanisms explaining this phenomenon across different tissues and emphasizes the implications for fibrosis in tissues with fibroblast and lipid-filled cell populations, such as the skin, lung, and liver.
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