Promising Antidiabetic Potential of Cuscuta Reflexa Leaves Methanol Extract in Alloxan-Induced Diabetic Rats

    May 2020 in “ Clinical Phytoscience ”
    Ronia Mostofa, Rayhana Begum, Hongbin Wang, Mst. Marium Begum, Rubaba Karim, Taslima Begum, Nur Alam Siddiquee, Rebeka Sultana, Sonia Sultana, Abul Kalam Lutful Kabir, Sumaiya Alam, Tasnuva Tasnim Nova
    Studysummary In this study, methanol extract of Cuscuta reflexa leaves significantly reduced blood glucose and improved insulin and liver function in alloxan-induced diabetic rats, indicating potential as an antidiabetic and organ-protective agent. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the antidiabetic potential of Cuscuta reflexa leaves methanol extract (CRME) in alloxan-induced diabetic Wistar albino rats over 45 days. CRME was administered in doses of 100, 200, and 400 mg/kg/day, and its effects were compared to gliclazide. Results showed that CRME significantly reduced blood glucose levels, with the highest dose achieving a reduction to 109.5 mg/dL compared to 249.7 mg/dL in the diabetic control group. CRME also improved HbA1C, insulin levels, liver function, and lipid profiles. Histopathological analysis indicated that CRME reversed diabetes-induced tissue changes, suggesting its potential as an antidiabetic and organ-protective agent. The study concluded that C. reflexa could be a promising alternative therapeutic agent for diabetes treatment, warranting further investigation into its bioactive compounds.
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