Droplet-Based Microfluidics as a Platform to Design Food-Grade Delivery Systems Based on the Entrapped Compound Type

The document reviews the use of droplet-based microfluidics for designing food-grade delivery systems, emphasizing the precise control over encapsulation and release of bioactive compounds. This technology improves upon conventional methods by creating monodisperse droplets, enhancing solubility, stability, and bioavailability of compounds like lipids and drugs. It highlights the use of food-grade materials such as carbohydrates, proteins, and lipids, and discusses the encapsulation of compounds like finasteride and rutin in PLGA microspheres and nanoparticles, respectively, demonstrating high encapsulation efficiency and controlled release. The review also addresses challenges in scaling up production and maintaining device efficiency, suggesting future research focus on high-throughput, easily operable microchips for industrial applications.