Apobds: A Paradigm Shift From Cellular Debris To Therapeutic Vehicles

    July 2025 in “ Frontiers in Endocrinology ”
    Zixuan Xiong, Fen Xiao, Yuanyuan Sun, Hankun Su, Di Liu, Beisha Tang, Wenyan Jian, Tianli Yang, Jing Zhao, Yanping Li, Hui Li
    TLDR ApoBDs, once seen as waste, are now viewed as potential tools for disease treatment and tissue repair.
    Apoptotic bodies (ApoBDs), once considered cellular debris, are now recognized as therapeutic vehicles with dual roles in disease promotion and treatment. This review discusses their formation, functions, and potential applications in cancer therapy, immune modulation, and tissue regeneration. ApoBDs contain bioactive molecules that can drive tumor growth and metastasis but also aid in tissue repair. The paper highlights the transformative potential of ApoBDs in modern medicine and addresses the challenges and future directions for their research and clinical use.
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