January 2025 in “Annals of Dermatology” In this study, 0.2 mg dutasteride significantly improved hair growth in men with androgenetic alopecia compared to placebo over 24 weeks, showing similar efficacy to the higher 0.5 mg dose with a favorable safety profile.
September 2023 in “Journal of movement disorders” In this study, 27.9% of Parkinson's disease patients reported hair loss, with a higher incidence linked to a daily levodopa-equivalent dose over 448 mg, suggesting an association between dopaminergic medication use and hair loss complaints.
23 citations
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January 2016 in “Frontiers in immunology” This review discusses the potential of combining low-dose IL-2 with islet antigens to enhance antigen-specific Treg function in type 1 diabetes, but reports no new clinical results.
1 citations
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November 2022 in “International journal of molecular sciences” This study found that local injections of fetal tissue mesenchymal stromal cells in mice significantly improved healing and hair follicle density after high-dose radiation-induced skin damage.
May 2025 in “CPT Pharmacometrics & Systems Pharmacology” This study examined the safety profile of ritlecitinib, a drug for alopecia areata, and found that it does not cause significant QTc prolongation or severe lymphopenia, with no unique safety risks expected in adolescents.
May 2025 in “International Journal of Trichology” This prospective study reported that 5 mg daily oral low-dose minoxidil over 24 weeks led to a high prevalence of hypertrichosis in 93% of male androgenetic alopecia patients, particularly affecting younger individuals, but generally had minimal impact on patients’ quality of life.
December 2024 in “Frontiers in Neurology” In this pilot randomized clinical trial, TRT combined with finasteride increased lean mass, muscle size, and bone mineral density without prostate enlargement in men with spinal cord injury, suggesting potential benefits for body composition and musculoskeletal health.
July 2023 in “Journal of Clinical Medicine” In this study, researchers investigated factors predicting resistance to clomiphene citrate in women with anovulatory PCOS, identifying AMH and SHBG levels as significant indicators, but they found no reliable thresholds for predicting resistance to the standard 50 mg/day dose.
August 2022 in “Journal of The American Academy of Dermatology” This study observed a slight reduction in blood pressure in normotensive patients after taking a 5-mg dose of oral minoxidil, particularly within the first two hours and more so in those with high baseline blood pressure.
28 citations
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September 2021 in “JAAD Case Reports” This study reports that the Pfizer-BioNTech COVID-19 vaccine showed 52% protection against COVID-19 after the first dose and 95% after the second in phase 3 trials.
15 citations
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April 2025 in “Journal of Clinical Medicine” This review reports that platelet-rich plasma may be more effective for musculoskeletal conditions when prepared with high platelet doses and low leukocyte content, but further trials are needed to confirm optimal formulations.
6 citations
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May 2021 in “Aesthetic Surgery Journal” This study found that intradermal injections of platelet-rich plasma were equally safe and effective for treating androgenetic alopecia, with higher platelet numbers possibly enhancing hair density and follicle diameter.
November 2025 in “Journal of Family Medicine and Primary Care” This systematic review and meta-analysis found that low-dose minoxidil treatment effectively enhances facial hair development with relatively minimal side effects, which can be beneficial in primary care settings.
14 citations
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December 2017 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses unconventional therapies for managing alopecia areata, highlighting antihistamines, cryotherapy, and low-dose naltrexone, but reports no new clinical results and emphasizes the need for further research.
January 2025 in “Clinical Dermatology Review” In this case report, a 16-year-old female with Netherton syndrome, a rare genetic disorder, exhibited symptoms such as skin issues, hair abnormalities, and elevated serum IgE levels. The diagnosis was supported by skin biopsy, and treatment included topical therapies, NB-UVB, and infliximab.
57 citations
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August 2023 in “American Journal of Clinical Dermatology” JAK inhibitors and platelet-rich plasma show promise for treating alopecia areata.
27 citations
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January 2017 in “Journal of clinical and diagnostic research” This case report details a 23-year-old woman who was poisoned with thallium by a colleague and treated with activated charcoal and Prussian blue.
21 citations
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May 2017 in “Paediatric drugs” Individualized treatment plans are crucial for children with alopecia areata, with promising options like JAK inhibitors showing significant hair regrowth.
4 citations
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April 2001 in “European journal of cancer” Scalp cooling prevented hair loss in half of the patients, despite significant side effects.
December 2025 in “International Journal of Innovative Technologies in Social Science” This review identified emerging therapies for androgenetic alopecia, such as low-dose oral minoxidil and stem cell-based treatments, which show promise for improved hair loss management but require standardized protocols and large-scale trials for further validation.
24 citations
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August 2020 in “JAMA dermatology” In this study, researchers observed a dose-dependent occurrence of persistent radiation-induced alopecia in patients with primary CNS tumors or head and neck sarcomas, noting distinctive patterns and features, and suggesting potential benefits of topical minoxidil and procedural interventions for treatment.
80 citations
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August 1991 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study found that low-dose methotrexate significantly reduced the steroid requirement in subjects with corticosteroid-requiring asthma without altering their clinical status or causing significant complications.
163 citations
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April 1953 in “Acta radiologica” Radiation therapy with a higher dose for the brain improves survival in cerebellar medulloblastoma.
80 citations
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January 1988 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study observed that high-dose spironolactone frequently caused metrorrhagia in women with idiopathic hirsutism, leading the authors to suggest lower starting doses or additional hormonal therapy.
18 citations
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August 1985 in “European journal of endocrinology” This study found that high-dose cyproterone acetate was effective for treating hirsutism, but 33% of patients felt their condition worsened on low-dose maintenance therapy, despite no significant change in objective measures of hair growth.
11 citations
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May 2000 in “International Journal of Dermatology” Taking a small dose of prednisone before menstruation can almost completely prevent premenstrual acne with few side effects.
2 citations
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May 2023 in “Al Mustansiriyah Journal of Pharmaceutical Sciences” This study found that high-dose pterostilbene potentially reduced prostate hyperplasia and had strong antioxidant effects in male rats with benign prostatic hyperplasia, suggesting it might be more effective than vitamin C and resveratrol in similar contexts.
127 citations
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June 2008 in “British Journal of Clinical Pharmacology” This study supports the conclusion that the hormetic dose-response model is the most prevalent and fundamental model in biological and biomedical sciences, applicable to a wide range of clinical conditions.
10 citations
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February 2008 in “International Journal of Andrology” This study found that a 400-mg dose of oral testosterone with dutasteride increases serum testosterone levels for 8–10 hours in hypogonadal men, with the nanomilled formulation unaffected by food, suggesting a practical twice-daily therapy option.
2 citations
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September 2007 in “International Journal of Impotence Research” This case study reports that low-dose testosterone therapy improved libido and sexual functions in a 36-year-old fragile X carrier female with hypoactive sexual desire disorder when monitored regularly for lab parameters.