Characteristics of Hypertrichosis Induced by 24-Week Low-Dose (5 mg Daily) Oral Minoxidil in Male Pattern Hair Loss Treatment

May 2025 in “ International Journal of Trichology ”

Suparuj Lueangarun, Ratchathorn Panchaprateep, Therdpong Tempark

minoxidil androgenetic alopecia hypertrichosis oral minoxidil Rogaine

Studysummary This prospective study reported that 5 mg daily oral low-dose minoxidil over 24 weeks led to a high prevalence of hypertrichosis in 93% of male androgenetic alopecia patients, particularly affecting younger individuals, but generally had minimal impact on patients’ quality of life.

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research Medical and Procedural Treatment of Androgenetic Alopecia – Where Are We?

August 2023 in “Journal of The American Academy of Dermatology”

This source highlights new developments in treating androgenetic alopecia, including low-dose oral minoxidil and advancements in photobiomodulation, platelet-rich plasma, and hair transplantation techniques, providing clinicians with more options.

Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

research Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

24 citations , September 2020 in “Dermatology and therapy”

This study found that low-dose oral minoxidil 5 mg daily significantly increased hair growth in men with androgenetic alopecia over 24 weeks, with increased hair count and vertex area improvement, though most experienced hypertrichosis and some had pedal edema.

research Characterization and Management of Hypertrichosis Induced by Low-Dose Oral Minoxidil in the Treatment of Hair Loss

7 citations , September 2020 in “Journal of The American Academy of Dermatology”

This article describes the characteristics and management of hypertrichosis induced by low-dose oral minoxidil used for hair disorders, but reports no new clinical findings.

research Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety

59 citations , July 2020 in “Journal of The American Academy of Dermatology”

This study concluded that oral minoxidil is an effective and well-tolerated alternative to topical minoxidil for healthy patients struggling with application-related compliance issues.

research Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone

80 citations , December 2017 in “International Journal of Dermatology”

This study reported that once-daily treatment with oral minoxidil and spironolactone for 12 months reduced hair loss severity and hair shedding in women with pattern hair loss, with generally mild side effects, though results came from an uncontrolled, observational pilot study.

research Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia

27 citations , November 2013 in “Dermatologic Therapy”

This study suggests that a hair follicle enzyme assay may predict response to minoxidil treatment for androgenetic alopecia with high sensitivity and specificity in a preliminary analysis.

research Pseudofolliculitis Barbae Induced by Oral Minoxidil

6 citations , May 2012 in “Clinical and experimental dermatology”

This article reports a case of pseudofolliculitis barbae potentially induced by the use of oral minoxidil.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.

research Histologic Response to Topically Applied Minoxidil in Male-Pattern Alopecia

38 citations , October 1988 in “Clinics in Dermatology”

Minoxidil can help grow hair and make hair follicles bigger, but it can also cause side effects.