Alleviation of Severe Skin Insults Following High-Dose Irradiation with Isolated Human Fetal Placental Stromal Cells

November 2022 in “ International journal of molecular sciences ”

Boaz Adani, Eli Sapir, Evgenia Volinsky, Astar Lazmi-Hailu, Raphael Gorodetsky

human fetal placental stromal cells f-hPSC hair regrowth hair follicle density skin rigidity radiation-induced skin injuries

TLDR Human fetal placental stromal cell injections speed up healing and improve skin and hair recovery after radiation damage.

The study investigated the effects of isolated human fetal placental stromal cells (f-hPSC) on severe skin damage caused by high-dose irradiation in mice. Mice treated with f-hPSC showed significantly improved skin condition, reduced lesion severity, and promoted hair regrowth compared to untreated irradiated controls. Histological analysis revealed higher hair follicle density and reduced skin rigidity in f-hPSC treated mice. These findings suggest that f-hPSC could be a promising treatment for radiation-induced skin injuries.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Skin Wound Healing in Humans and Mice: Challenges in Translational Research

276 citations, December 2017 in “Journal of Dermatological Science”

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Related Community Posts Join

6 / 1000+ results

community Verteporfin and Microneedling

in Treatments 1 year ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 106 upvotes 4 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 11 months ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community Stopping Dutasteride to have a baby

in Finasteride/Dutasteride 70 upvotes 9 months ago

A user plans to stop Dutasteride to conceive a child, seeking advice on hair maintenance. Suggestions include switching to Finasteride, but many emphasize prioritizing child safety.

community Just find a cure already, I am totally done

in Chat 161 upvotes 1 year ago

The conversation is about hair loss treatments, with users recommending finasteride and minoxidil as effective solutions. Some users report side effects, but overall, the consensus is to use these treatments rather than waiting for a cure.

community Hair came back in 3 months at 39y/o.

in Progress Pictures 421 upvotes 1 year ago

A user shared their successful hair regrowth using a combination of minoxidil, caffeine, biotin, and RU58841, along with weekly dermarolling. However, others advised against the user's plan to switch to rosemary oil and microneedling only, emphasizing the importance of continuing the current treatment to maintain the results.

Related Research

7 / 7 results

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations, August 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research Safety and Efficacy of Trimax-360 Serum in Healthy Adult Subjects with Mild to Moderate Alopecia of the Scalp

April 2022 in “Journal of Cosmetic Dermatology”

Trimax-360 Serum, when used for 98 days, safely and effectively improves hair growth, thickness, and density without any side effects.

research Significant Relationship Between Temporal Hair Loss and Other Scalp Areas in Female Pattern Hair Loss

5 citations, January 2020 in “Journal of Dermatology”

Temporal hair loss relates to overall scalp hair loss in women.

research Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle

24 citations, November 2013 in “Trends in pharmacological sciences”

Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations, January 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

The Changing Patterns of Hair Density and Thickness in South Korean Women with Hair Loss: Clinical Office-Based Phototrichogram Analysis

research The Changing Patterns of Hair Density and Thickness in South Korean Women with Hair Loss: Clinical Office-Based Phototrichogram Analysis

41 citations, December 2008 in “International Journal of Dermatology”

South Korean women with hair loss have lower hair density and thickness compared to healthy women.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations, July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.