Trichoscopy in Unveiling the Triad of Netherton Syndrome

January 2025 in “ Clinical Dermatology Review ”

H Bangaru, D Ashwini

Netherton syndrome congenital ichthyosiform erythroderma hair shaft abnormalities atopic diathesis trichorrhexis invaginata isotretinoin trichoscopy NS brittle hair scaly skin lesions low-dose isotretinoin

Studysummary In this case report, a 16-year-old female with Netherton syndrome, a rare genetic disorder, exhibited symptoms such as skin issues, hair abnormalities, and elevated serum IgE levels. The diagnosis was supported by skin biopsy, and treatment included topical therapies, NB-UVB, and infliximab. Our plain-language summary of this paper — not a Tressless recommendation.

The document discusses a case of Netherton syndrome (NS), a rare genetic disorder characterized by congenital ichthyosiform erythroderma, hair shaft abnormalities, and atopic diathesis. The case involves a 16-year-old girl with symptoms including scaly skin lesions, brittle hair, and high serum IgE levels. Trichoscopy revealed characteristic hair abnormalities such as trichorrhexis invaginata, aiding in diagnosis. Treatment with low-dose isotretinoin showed improvement in skin lesions. The report emphasizes the importance of recognizing NS, which is often misdiagnosed as atopic dermatitis, and highlights trichoscopy as a valuable diagnostic tool.

View this study on journals.lww.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Trichoscopy as a Diagnostic Tool in Trichorrhexis Invaginata and Netherton Syndrome

30 citations , February 2015 in “Anais Brasileiros de Dermatologia”

This case report describes a 4-year-old boy with Netherton syndrome, where trichoscopy importantly aided diagnosis and is recommended for all children with erythroderma.